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N1517

Sigma-Aldrich

N-Nitroso-N-methylurea

ISOPAC®

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Synonym(s):
MNU, N-Methyl-N-nitrosourea
Empirical Formula (Hill Notation):
C2H5N3O2
CAS Number:
684-93-5
Molecular Weight:
103.08
MDL number:
MFCD00014794
UNSPSC Code:
12352200
PubChem Substance ID:
24897498

storage temp.

2-8°C

SMILES string

CN(N=O)C(N)=O

InChI

1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)

InChI key

ZRKWMRDKSOPRRS-UHFFFAOYSA-N

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Biochem/physiol Actions

DNA alkylating agent that is carcinogenic in many animal species. Although it can induce benign and malignant tumors in most organs, MNU is most often used to model mammary tumor initiation and progression.

Packaging

Packaged in a 100 mL serum bottle with butyl rubber stopper and aluminum tear seal.

Caution

Injecting any compatible solvent directly into the vial permits preparation of any desired strength solution without exposure.

Reconstitution

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Legal Information

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

ISOPAC of

Product No.
Description
Pricing

Signal Word

Danger

Hazard Statements

H228,H301,H350,H360

Precautionary Statements

P201 - P210 - P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Flam. Sol. 2 - Repr. 1B

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the purity of N-Nitroso-N-methylurea - ISOPAC®, Product N1517?

    Product No. N1517 is not assayed for purity.

  4. Is N-Nitroso-N-methylurea - ISOPAC®, Product N1517, hazardous material?

    Yes, N-Nitroso-N-methylurea (MNU) is extremely hazardous. It is a known carcinogen. N1517 is packaged as an ISOPAC so that the material does not need to weighed out. Any precautions that one can take to minimize handling the material would be advisable.

  5. What is N-Nitroso-N-methylurea - ISOPAC®, Product N1517, soluble in?

    Dissolving the contents in 100 mL of solvent yields a 1% solution. We would recommend using either ethanol or DMSO as the solvent. MNU has very poor stability in aqueous solutions.

  6. The package size of N-Nitroso-N-methylurea - ISOPAC®, Product N1517, is 1 gram (N1517-1G), but I see that this product also contains acetic acid and water. How much of each is in the bottle?

    Each bottle contains 1 gram of MNU. There is a significant amount of acetic acid and water present; the specific quantities are given on the certificate of analysis of each lot. Including the acetic acid and water, the total amount of material in each bottle will typically be in the 1-2 gram range.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Carcinogenesis, 33(11), 2242-2249 (2012-07-27)
Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible 'mega' doses for achieving detectable tissue levels.
Alice A Ramos et al.
Journal of toxicology and environmental health. Part A, 75(13-15), 765-775 (2012-07-14)
DNA damage induced by oxidative and alkylating agents contributes to carcinogenesis, leading to possible mutations if replication proceeds without proper repair. However, some alkylating agents are used in cancer therapy due to their ability to induce DNA damage and subsequently
Marzena Kurowska et al.
Mutation research, 738-739, 52-70 (2012-10-23)
We present studies aimed at determining the types and frequencies of mutations induced in the barley genome after treatment with chemical (N-methyl-N-nitrosourea, MNU) and physical (gamma rays) mutagens. We created M(2) populations of a doubled haploid line and used them
Kawiya Sintara et al.
Journal of biomedicine & biotechnology, 2012, 915380-915380 (2012-06-13)
To determine effects of curcumin on N-methyl-N-nitrosourea (MNU) and saturated sodium chloride (s-NaCl)-induced gastric cancer in rats. Male Wistar rats were divided into 5 groups: control (CO), control supplemented with 200 mg/kg curcumin (CC), MNU + s-NaCl, MNU + s-NaCl supplemented with 200 mg/kg curcumin daily
Bianca F Gonçalves et al.
The Prostate, 73(11), 1202-1213 (2013-04-27)
Characterization of novel rodent models for prostate cancer studies requires evaluation of either spontaneous and carcinogen-induced tumors as well as tumor incidence in different prostatic lobes. We propose a new short-term rodent model of chemically induced prostate carcinogenesis in which
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