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N1415

Sigma-Aldrich

Naratriptan hydrochloride

≥98% (HPLC)

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Synonym(s):
Amerge, GR-85548A, N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride
Empirical Formula (Hill Notation):
C17H25N3O2S ·HCl
CAS Number:
143388-64-1
Molecular Weight:
371.93
MDL number:
MFCD08141821
UNSPSC Code:
12352200
PubChem Substance ID:
329818579
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H2O: ≥10 mg/mL

originator

GlaxoSmithKline

storage temp.

room temp

SMILES string

Cl.CNS(=O)(=O)CCc1ccc2[nH]cc(C3CCN(C)CC3)c2c1

InChI

1S/C17H25N3O2S.ClH/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14;/h3-4,11-12,14,18-19H,5-10H2,1-2H3;1H

InChI key

AWEZYKMQFAUBTD-UHFFFAOYSA-N

Gene Information

human ... HTR1B(3351) , HTR1D(3352)

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Biochem/physiol Actions

Naratriptan hydrochloride is a triptan drug that is used to relieve acute migraine headaches. It has poor bioavailability, short half-life, and the incidence of migraine recurrence therefore, it is occasionally used.
Naratriptan hydrochloride is a serotonin 5-HT1B/1D receptor agonist.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Formulation and evaluation of thermoreversible mucoadhesive in-situ gel for intranasal delivery of naratriptan hydrochloride
Shelke S, et al.
Journal of drug delivery science and technology, 238-244 (2015)
Estimation of Naratriptan Hydrochloride in Bulk and Formulation by First Order Derivative UV-Spectrophotometric Methods
Borse JS and Shirkhedkar AA
Journal of Applied Pharmaceutical Science, 227-227 (2012)

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