N0399
Anti-Nix antibody produced in rabbit
1 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-BNIP3α, Anti-BNIP3L
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About This Item
UNSPSC Code:
12352203
MDL number:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 38 kDa
species reactivity
human, mouse
concentration
1 mg/mL
technique(s)
western blot: 0.5-1 μg/mL using a K562 cell lysate.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... BNIP3L(665)
mouse ... Bnip3l(12177)
General description
BCL2/adenovirus E1B 19kDa interacting protein 3-like (BNIP3L) is expressed in the outer membrane of mitochondria. The BNIP3L gene is localized on human chromosome 8p21.
Immunogen
synthetic peptide corresponding to amino acids 77-92 of an internal domain of human Nix. This peptide is identical in mouse.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
BCL2/adenovirus E1B 19kDa interacting protein 3-like (BNIP3L) associates with proteins which are anti-apoptotic, like B-cell lymphoma 2 (Bcl-2). It also takes part in the growth of the erythroid lineage. Expression of BNIP3L is downregulated in lung cancer cells in vitro.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Paul A Ney
Biochimica et biophysica acta, 1853(10 Pt B), 2775-2783 (2015-03-11)
Mitochondrial autophagy (mitophagy) is a core cellular activity. In this review, we consider mitophagy and related cellular processes and discuss their significance for human disease. Strong parallels exist between mitophagy and xenophagy employed in host defense. These mechanisms converge on
Ana Guerra-Librero et al.
Antioxidants (Basel, Switzerland), 10(4) (2021-05-01)
Metabolic reprogramming, which is characteristic of cancer cells that rapidly adapt to the hypoxic microenvironment and is crucial for tumor growth and metastasis, is recognized as one of the major mechanisms underlying therapeutic resistance. Mitochondria, which are directly involved in
Ying-Qiang Shen et al.
Journal of pineal research, 64(3) (2017-12-17)
Head and neck squamous cell carcinoma (HNSCC) clearly involves activation of the Akt mammalian target of rapamycin (mTOR) signalling pathway. However, the effectiveness of treatment with the mTOR inhibitor rapamycin is often limited by chemoresistance. Melatonin suppresses neoplastic growth via
M Matsushima et al.
Genes, chromosomes & cancer, 21(3), 230-235 (1998-04-02)
We have isolated a novel cDNA that encodes a product showing significant sequence homology (56% identity) to human NIP3, a protein thought to interact with adenovirus E1B19kD and human BCL2 proteins. This cDNA contains an open reading frame of 657
Yaiza Potes et al.
Aging and disease, 10(2), 217-230 (2019-04-24)
Aging is characterized by a progressive loss of skeletal muscle mass and function (sarcopenia). Obesity exacerbates age-related decline and lead to frailty. Skeletal muscle fat infiltration increases with aging and seems to be crucial for the progression of sarcopenia. Additionally
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