MAK399
COX-2 Inhibitor screening kit
sufficient for 100 fluorometric tests
Synonym(s):
Cyclooxygenase-2 Inhibitor Test Kit
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About This Item
UNSPSC Code:
12161503
Recommended Products
detection method
fluorometric
relevant disease(s)
rheumatological diseases
storage temp.
−20°C
General description
Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for the formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. COX is the central enzyme in the biosynthetic pathway to prostanoids from arachidonic acid. There are two known isoenzymes: COX-1 and COX-2. COX-1 is constitutively expressed in many tissues and is the predominant form in gastric mucosa and in kidney. COX-2 is not expressed under normal conditions in most cells, but elevated levels are found during inflammation. Pharmacological inhibition of COX by non-steroidal anti-inflammatory drugs (NSAID) can provide relief from the symptoms of inflammation and pain.
Features and Benefits
COX-2 Inhibitor Screening Kit:
- Compatible with high-throughput handling systems.
Suitability
The kit is suitable for screening, studying and characterizing COX-2 inhibitors.
Principle
The assay is based on the fluorometric detection of Prostaglandin G2, the intermediate product generated by the COX enzyme.
Storage Class Code
10 - Combustible liquids
Regulatory Information
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