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Safety Information

MAK378

Sigma-Aldrich

Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit

100 fluorometric tests

Synonym(s):

ACE2 Inhibitor Discovery Kit

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Select a Size

1 L
CN¥563.70
4 L
CN¥2,144.58
10 L
CN¥5,071.06

CN¥563.70

Please contact Customer Service for Availability
Request a Bulk Order
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1 L
CN¥563.70
4 L
CN¥2,144.58
10 L
CN¥5,071.06

About This Item

UNSPSC Code:
12161503
NACRES:
NA.84

CN¥563.70

Please contact Customer Service for Availability
Request a Bulk Order

usage

100 fluorometric tests

application(s)

pharmaceutical

detection method

fluorometric

relevant disease(s)

immunological diseases; cardiovascular diseases; genitourinary disorders; pulmonary disorders

storage temp.

−20°C

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product line

Certipur®

product line

Certipur®

product line

Certipur®

product line

Certipur®

grade

certified reference material

grade

certified reference material

grade

certified reference material

grade

certified reference material

application(s)

environmental
food and beverages
general analytical
industrial qc
pharmaceutical

application(s)

environmental
food and beverages
general analytical
industrial qc
pharmaceutical

application(s)

environmental
food and beverages
general analytical
industrial qc
pharmaceutical

application(s)

environmental
food and beverages
general analytical
industrial qc
pharmaceutical

pH

4.0 (20 °C in H2O)

pH

5.0 (25 °C in H2O)

pH

7.0 (20 °C in H2O)

pH

1.0 (25 °C in H2O)

density

1.01 g/cm3 at 20 °C

density

1.01 g/cm3 at 20 °C

density

1.01 g/cm3 at 20 °C

density

1.00 g/cm3 at 20 °C

General description

Angiotensin II converting enzyme (ACE2), a carboxypeptidase, is part of the renin-angiotensin system (RAS) that controls regulation of blood pressure by cleaving the C-terminal dipeptide of Angiotensin II to convert it into Angiotensin 1-7. It also cleaves Angiotensin I to produce Ang 1-9, of unknown function. ACE2 is a receptor of human coronaviruses, such as SARS and HCoV-NL63. It is expressed on the vascular endothelial cells of heart and kidney. The inhibitors of ACE2 could be able to regulate hypertension by changing vascular permeability. Screening for small molecule and peptide inhibitors might also help in finding treatment for coronavirus mediated infection.

Features and Benefits

The Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit is compatible with high-throughput handling systems.

Suitability

The kit is suitable for Screening/characterizing inhibitors/ligands of ACE2.

Principle

The Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit can be used to screen for potent inhibitors of ACE2 activity, it utilizes the ability of an active ACE2 to cleave a synthetic MCA based peptide substrate to release a free fluorophore. The released MCA can be easily quantified using a fluorescence microplate reader. In the presence of an ACE2 specific inhibitor, the enzyme loses its peptidase activity which results in decrease of fluorescence intensity.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Regulatory Information

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    Certificates of Analysis (COA)

    Lot/Batch Number
    7L02K03100
    7E07K03100

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