MAK243
Thrombin Inhibitor Screening Kit (Fluorometric)
sufficient for 100 fluorometric tests
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.25
Recommended Products
detection method
fluorometric
relevant disease(s)
hematological disorder
storage temp.
−20°C
General description
Thrombin enzyme (Factor IIa) is an important clotting factor that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin inhibitors are used as anticoagulants to prevent arterial and venous thrombosis. Some of these inhibitors are currently in clinical use while others are in clinical development.
Suitability
Suitable for screening potential inhibitors of thrombin and characterizing/studying thrombin inhibitors in plasma samples.
Principle
This Thrombin Inhibitor Screening Kit utilizes the ability of thrombin to cleave a synthetic AMC-based peptide substrate to release AMC, which can be detected by measuring its fluorescence (λex = 350 nm/λem = 450 nm). In the presence of thrombin specific inhibitors, the cleavage reaction is reduced or completely abolished. The loss in the fluorescence intensity can be correlated to the amount of inhibitor present in the assay solution. The kit provides a simple and rapid method to screen potential inhibitors of thrombin.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Flam. Liq. 3
Storage Class Code
3 - Flammable liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
监管及禁止进口产品
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Srinivas Chamakuri et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(36) (2021-08-25)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 4 million humans globally, but there is no bona fide Food and Drug Administration-approved drug-like molecule to impede the COVID-19 pandemic. The sluggish pace of traditional therapeutic discovery is
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