MAK209
Granzyme B Inhibitor Screening Kit
Sufficient for 100 Fluorometric tests
Synonym(s):
GZMB Inhibitor Screening Kit
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About This Item
UNSPSC Code:
12352200
EC Number:
200-664-3
NACRES:
NA.25
detection method
fluorometric
relevant disease(s)
immunological diseases; orthopedic diseases; cardiovascular diseases; rheumatological diseases
storage temp.
−20°C
Gene Information
human ... GZMB(3002)
mouse ... GZMB(14939)
rat ... GZMB(171528)
General description
Granzyme B (GZMB; EC 3.4.21.79) is a serine protease stored in the secretory granules of leukocytes. It induces cytotoxic T lymphocyte (CTL)-mediated apoptosis by the activation of caspases and the degradation of structural proteins of the target cells. Granzyme B has an important role in CTL-mediated immune responses and has been implicated in chronic inflammatory diseases such as rheumatoid arthritis, coronary syndrome, and chronic angina pectoris.
Application
Suitable for the screening of inhibitors of Granzyme B.
Biochem/physiol Actions
The Granzyme B Inhibitor Screening Kit is a simple and high-throughput assay for screening potential inhibitors of granzyme B. Granzyme B activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex = 380/ λem = 500 nm), proportional to the enzymatic activity present. The substrate includes the recognition sequence for granzyme B.
Features and Benefits
Compatible with high-throughput handling systems.
Kit Components Only
Product No.
Description
- Granzyme B Assay Buffer
- Granzyme B Substrate
- Granzyme B Enzyme
- Inhibitor Control, Ac-IEPD-CHO
Storage Class
10 - Combustible liquids
Regulatory Information
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