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MAK203

Sigma-Aldrich

DPP4 INHIBITOR SCREENING KIT

Sufficient for 100 Fluorometric tests

Synonym(s):

Adenosine Deaminase Complexing Protein-2 Inhibitor Screening Kit, CD26 Inhibitor Screening Kit, Dipeptidyl-Peptidase 4 Inhibitor Screening Kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.25

application(s)

pharmaceutical

detection method

fluorometric

relevant disease(s)

endocrinological disorders, diabetes

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... DPP4(1803)
mouse ... DPP4(13482)
rat ... DPP4(25253)

General description

Dipeptidyl-peptidase 4 (DPP4; CD26; adenosine deaminase complexing protein-2) is a membrane glycoprotein with serine exopeptidase activity that cleaves X-proline dipeptides from the N-terminus of polypeptides. Inhibitors of DPP4 inhibit the degradation of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 by DPP4 and have emerged as oral anti-diabetic agents.

Features and Benefits

Compatible with high-throughput handling systems.

Suitability

Suitable for the screening of inhibitors of DPP4.

Principle

The DPP4 Inhibitor Screening Kit is a simple assay suitable for high-throughput screening of potential DPP4 inhibitors. DPP4 activity is measured by cleaving the substrate to yield a fluorescent product (λex = 360/λem = 460 nm), proportional to the enzymatic activity present. The effectiveness of the test inhibitors may be compared with the DPP4 inhibitor (sitagliptin) provided as a control.

Kit Components Only

Product No.
Description
  • DPP4 Assay Buffer
  • DPP4 Substrate
  • DPP4 Enzyme
  • DPP4 Inhibitor, Sitagliptin

Storage Class Code

10 - Combustible liquids

Flash Point(F)

188.6 °F - closed cup

Flash Point(C)

87 °C - closed cup

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Paulina Kęska et al.
Nutrients, 14(4) (2022-02-27)
The ability of peptides from an aqueous and salt-soluble protein extract of dry-cured pork loins to inhibit the action of dipeptidyl peptidase IV was determined. This activity was assessed at different times of the production process, i.e., 28, 90, 180
Bingli Zhao et al.
Bioorganic chemistry, 99, 103772-103772 (2020-03-29)
Two key enzymes like α-glucosidase and dipeptidyl peptidase-4 (DPP4) play an important role in the development of Type 2 diabetes (T2D), and inhibiting them is a common treatment strategy for T2D. In this study, an ultrafiltration- centrifugation approach was developed
Cleni Palma-Albino et al.
Antioxidants (Basel, Switzerland), 10(11) (2021-11-28)
Multifunctional peptides, capable of acting on different body systems through multiple mechanisms of action, offer many advantages over monofunctional peptides, including lower adverse side effects and costs. Erythrina edulis (pajuro) is a legume with a large number of high-quality proteins
S Wupper et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 71(3) (2020-09-30)
Gamma-cyclodextrin (γCD) is a cyclic oligosaccharide consisting of eight α-(1,4)-linked glucopyranose subunits, which is often used in the food and pharmaceutical industries. However, little is known regarding the metabolic activity of "empty" γCD per se. Therefore, in the present study

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