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Merck
CN

MAK197

Succinate Dehydrogenase Assay Kit

Sufficient for 100 Colorimetric tests

Synonym(s):

SDH Activity Assay Kit

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About This Item

NACRES:
NA.84
UNSPSC Code:
12161503

Key Documents

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Product Name

Succinate Dehydrogenase Assay Kit, Sufficient for 100 Colorimetric tests

detection method

colorimetric

relevant disease(s)

neurological disorders

storage temp.

−20°C

Gene Information

human ... SDHA(6389), SDHAF1(644096), SDHAF2(54949), SDHB(6390), SDHC(6391), SDHD(6392)
mouse ... SDHA(66945), SDHAF1(68332), SDHAF2(66072), SDHB(67680), SDHC(66052), SDHD(66925)
rat ... SDHA(157074), SDHAF2(361726), SDHB(298596), SDHC(289217), SDHD(363061)

Application

Succinate Dehydrogenase Activity Colorimetric Assay Kit has been used to measure the enzyme activity of succinate dehydrogenase in samples.
Suitable for the detection of Succinate Dehydrogenase Activity in a variety of biological samples such as cell and tissue culture supernatants and purified mitochondria.

Biochem/physiol Actions

The Succinate Dehydrogenase Activity Colorimetric Assay kit provides a simple and sensitive procedure for measuring SDH activity in a variety of tissues, cells, and isolated mitochondria. SDH activity is determined by generating a product with absorbance at 600 nm proportional to the enzymatic activity present. One unit of SDH is the amount of enzyme that generates 1.0 μmole of DCIP per minute at pH 7.2 at 25 °C.

General description

Succinate dehydrogenase (SDH; EC 1.3.5.1) is a mitochondrial enzyme that catalyzes the oxidation of succinate to fumarate and carries electrons from FADH to CoQ in eukaryotes and bacteria. It has a central function in the maintenance of cellular energy metabolism via the Krebs (tricarboxylic acid) cycle and the electron transport chain. Mutations in SDH cause hereditary paraganglioma/phaeochromocytoma syndrome and a neurodegenerative disorder known as Leigh syndrome.

Storage Class

10 - Combustible liquids

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
8E18K06600
8A14K06600
7C11K06600
6G23K06600
6B06K06600

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