MAK110
MTP Activity Assay Kit
Supplied by Roar Biomedical, Inc.
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Synonym(s):
MTTP Activity Assay Kit, Microsomal triglyceride transfer protein activity assay kit
UNSPSC Code:
12161503
NACRES:
NA.84
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usage
sufficient for 100 fluorometric tests
application(s)
pharmaceutical
detection method
fluorometric
relevant disease(s)
cardiovascular diseases
storage temp.
2-8°C
Gene Information
human ... MTTP(4547)
Related Categories
General description
Microsomal triglyceride transfer protein (MTP), a membrane-bound protein present in the liver, plays an important role in the assembly and secretion of very low density lipoprotein (VLDL). MTP is also necessary for assembly and secretion of chylomicrons by the intestine. This protein facilitates the transfer of triglyceride (TG), cholesteryl ester (CE) and phosphatidylcholine (PC) between phospholipid surfaces. Mutation in the MTP gene leads to abetalipoproteinemia.
Application
MTP Activity Assay Kit has been used to measure the activity of microsomal triglyceride transfer protein (MTP).
Features and Benefits
Compatible with high-throughput handling systems.
Suitability
Suitable for measuring microsomal [triglyceride] transfer protein (MTP) activity in cell lysates or tissue homogenates, or for screening MTP activity inhibitors.
Principle
The MTP Activity Assay Kit is a sensitive, homogeneous fluorometric assay useful for continuous measurement of MTP activity in cell lysate or tissue homogenate. This kit includes proprietary substrates that enable the detection of MTP-mediated transfer of neutral lipid. The transfer activity results in an increase in fluorescence intensity (λEx=465 nm/λEm=535 nm).
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Regulatory Information
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J Estellé et al.
Animal genetics, 40(6), 813-820 (2009-06-06)
Despite the economic interest of the fatty acid profile in pigs, no gene has been convincingly associated with this trait so far. Here, the porcine microsomal triglyceride transfer protein (MTTP) gene, which plays a crucial role in the assembly of
Yuan-Lung Cheng et al.
Clinical science (London, England : 1979), 125(9), 439-448 (2013-05-11)
HCV (hepatitis C virus) infection affects an estimated 180 million people in the world's population. Adverse effects occur frequently with current standard treatment of interferon and ribavirin, while resistance of new direct anti-viral agents, NS3 protease inhibitors, is a major
Qinyuan Ye et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 43(10), 1115-1123 (2013-02-21)
To investigate the role of Cytochrome P4502E1 in sensitizing Kupffer cells to lipopolysaccharide (LPS)-mediated inflammation after ethanol induction. Sprague-Dawley rats were fed a liquid ethanol diet, control diet or ethanol diet supplemented with CYP2E1 inhibitor, chlormethiazole (CMZ), for 4 weeks. Hepatic
Short-term palmitate supply impairs intestinal insulin signaling via ceramide production.
Tran T T T, et al.
The Journal of Biological Chemistry, M115-M115 (2016)
J Massart et al.
British journal of pharmacology, 165(5), 1361-1374 (2011-07-12)
Pentoxifylline is in clinical trials for non-alcoholic fatty liver disease and diabetic nephropathy. Metabolic and hepatic effects of pentoxifylline were assessed in a murine model of obesity and type 2 diabetes. Pentoxifylline (100 mg·kg(-1) ·day(-1)) was administered for 4 days
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