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MAK101

Sigma-Aldrich

PAH (p-Aminohippuric Acid) Assay Kit

sufficient for 100 colorimetric tests

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.25

usage

sufficient for 100 colorimetric tests

detection method

colorimetric

relevant disease(s)

genitourinary disorders

storage temp.

−20°C

General description

p-Aminohippuric acid (PAH), a derivative of hippuric acid, is used in the measurement of renal plasma flow (RPF). Renal plasma flow measures the volume of plasma, which enters the kidney in a given period of time. To determine effective renal plasma flow, PAH is measured in a plasma sample (PPAH) and a urine sample (UPAH). The volume of urine flow (V) is also required.

Suitability

Suitable for measuring PAH (p-Aminohippuric Acid) in plasma and urine samples

Principle

The PAH (p-Aminohippuric Acid) Assay kit can be used for measuring PAH in a plasma and urine samples. PAH reacts with 4-(dimethylamino)cinnamaldehyde (DACA) to generate a compound, which can be detected spectrophotometrically at 550 nm.

Pictograms

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Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Regulatory Information

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Evaluation of change in blood flow by contrast?enhanced power Doppler imaging during norepinephrine?induced renal vasoconstriction.
Arger P H, et al.
Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine, 18(12), 843-851 (1999)
Tumor necrosis factor induces glomerular damage in the rabbit.
Bertani T, et al.
The American Journal of Pathology, 134(2), 419-419 (1989)
Cesar A Romero et al.
American journal of physiology. Renal physiology, 316(1), F195-F203 (2018-11-08)
The antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is released from thymosin-β4 (Tβ4) by the meprin-α and prolyl oligopeptidase (POP) enzymes and is hydrolyzed by angiotensin-converting enzyme (ACE). Ac-SDKP is present in urine; however, it is not clear whether de novo tubular release

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