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MAK100

Sigma-Aldrich

Inosine Assay Kit

sufficient for 100 fluorometric tests

Synonym(s):

Inosine Fluorometric Assay Kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84

usage

sufficient for 100 fluorometric tests

detection method

fluorometric

relevant disease(s)

cardiovascular diseases; immunological diseases

storage temp.

−20°C

General description

Inosine is a purine nucleotide found at the wobble position of tRNA where it plays a role in the proper translation of mRNA at the ribosome. In addition to its role in translation, inosine also plays important roles in the immune system where is exhibits both inflammatory and anti-inflammatory effects. Inosine may be tissue protective during ischemic injury and recent reports suggest inosine may preserve cell viability during hypoxia.

Application

Inosine Assay Kit has been used for the detection of inosine in the brain tissue homogenates.

Suitability

Suitable for the measurement of inosine in a variety of samples including tissue and cells

Principle

The Inosine Assay Kit provides a simple and direct procedure for measuring inosine in a variety of samples. Inosine concentration is determined by a coupled enzyme reaction in which inosine is converted to hypoxanthine which reacts with the substrate mix and probe, resulting in a fluorometric product (λex = 535/λem = 587 nm), proportional to the inosine present.

Storage Class Code

10 - Combustible liquids

Flash Point(F)

188.6 °F - closed cup

Flash Point(C)

87 °C - closed cup

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cell-subtype-specific changes in adenosine pathways in schizophrenia.
O?Donovan S M, et al.
Neuropsychopharmacology, 43, 1667?1674-1667?1674 (2018)
Sinead Marie O'Donovan et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 43(8), 1667-1674 (2018-02-28)
Prior work in animal models implicates abnormalities of adenosine metabolism in astrocytes as a possible pathophysiological mechanism underlying the symptoms of schizophrenia. In the present study, we sought to reverse-translate these findings back to the human brain in schizophrenia, focusing
Ariadna Sitjà-Bobadilla et al.
Parasites & vectors, 12(1), 486-486 (2019-10-18)
In the animal production sector, enteritis is responsible for serious economic losses, and intestinal parasitism is a major stress factor leading to malnutrition and lowered performance and animal production efficiency. The effect of enteric parasites on the gut function of

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