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Merck
CN

MAK071

Pyruvate Assay Kit

sufficient for 100 colorimetric or fluorometric tests

Synonym(s):

Assay Kit for Pyruvate Detection

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About This Item

NACRES:
NA.84
UNSPSC Code:
12161503

Key Documents

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Product Name

Pyruvate Assay Kit, sufficient for 100 colorimetric or fluorometric tests

usage

sufficient for 100 colorimetric or fluorometric tests

detection method

colorimetric
fluorometric

relevant disease(s)

gastrointestinal diseases; cancer

storage temp.

−20°C

Gene Information

human ... PKLR(5313), PKM2(5315)
mouse ... PKLR(18770), PKM2(18746)
rat ... PKLR(24651), PKM2(25630)

Application

Suitable for measuring pyruvate concentration in various biological samples such as blood, tissues, and culture cells.

Biochem/physiol Actions

Pyruvate concentration is determined by a coupled enzyme assay, which results in a colorimetric (570 nm)/fluorometric (λex = 535/λem = 587 nm) product, proportional to the pyruvate present.

General description

Pyruvate is a central molecule in metabolism that is used and synthesized through multiple metabolic pathways including glycolysis and the transamination of alanine. Pyruvate may be further oxidized in the citric acid cycle, converted to carbohydrates during gluconeogenesis, or reduced to lactate. High levels of pyruvate are associated with liver disease and genetic disorders. Pyruvate has also been used to stimulate metabolism leading to loss of body weight.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Resp. Sens. 1 - Skin Sens. 1

Storage Class

10 - Combustible liquids

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
8J15K06090
8B28K06090
7L22K06090
7F07K06090
7A04K06090

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Lauren K Wareham et al.
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De Palma S, et al.
PLoS ONE, 8(2), e56716-e56716 (2013)
Abstracts of the XVIth International Conference on Biological Inorganic Chemistry, July 22-26, 2013, Grenoble, France.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 19 Suppl 1, 1-696 (2014-03-13)
Xiaolong Zhang et al.
Biotechnology and bioengineering, 115(9), 2217-2231 (2018-06-14)
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Natarajaseenivasan K, et al.
Cell Death & Disease, 9(4), 415-415 (2018)
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