MAK041
β-Hydroxybutyrate Assay Kit
sufficient for 100 colorimetric tests
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.84
Recommended Products
usage
sufficient for 100 colorimetric tests
detection method
colorimetric
relevant disease(s)
endocrinological disorders, diabetes; cancer; gastrointestinal diseases
storage temp.
−20°C
General description
β-Hydroxybutyrate, also known as 3-Hydroxy-butyrate, is a ketone body primarily synthesized in the liver from the oxidation of fatty acids. Ketone body formation, ketogenesis, is elevated when blood glucose levels drop. Moderately elevated blood ketone bodies occur normally during fasting and prolonged exercise. During alcoholic or diabetic ketoacidosis, blood levels of β-hydroxybutyrate can rise to abnormally high levels. β-hydroxybutyrate can be used as a marker for hepatic energy metabolism. β-hydroxybutyrate formation increases with excessive acetyl-CoA, and serves as a source of energy to the brain.
Application
β-Hydroxybutyrate Assay Kit has been used
- to quantify the level of β-hydroxybutyrate in plasma/serum
- to study the change in myocardial 18F-FDG uptake upon extended ketogenic diet, by measuring the level of plasma ketone bodies
- to study the role of β-hydroxybutyrate in the treatment of impairment and neuropathic pain in spinal cord-injured mice
Suitability
Suitable for the measurement β-Hydroxybutyrate levels in biological samples including serum and urine
Principle
In this assay, β-Hydroxybutyrate concentration is determined by a coupled enzyme reaction, which results in a colorimetric (450 nm) product, proportional to the β-Hydroxybutyrate present.
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Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Storage Class Code
8A - Combustible corrosive hazardous materials
Regulatory Information
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Skeletal muscle IL-6 and regulation of liver metabolism during high-fat diet and exercise training.
Knudsen J G, et al.
Physiological Reports, 4(9), e12788-e12788 (2016)
Yongsheng Yu et al.
European journal of pharmacology, 829, 121-128 (2018-04-22)
The present study was designed to examine the protection of D-β-hydroxybutyrate (BHB) against ischemia/reperfusion (I/R) injury in heart and investigate its underlying mechanism. Male adult mice were exposed to 30 min of ischemia and 24 h of reperfusion. Osmotic pumps were implanted
Jenni Määttä et al.
Scientific reports, 8(1), 13583-13583 (2018-09-13)
Hypoxia of residence at high altitude (>2500 m) decreases birth weight. Lower birth weight associates with infant mortality and morbidity and increased susceptibility to later-in-life cardiovascular and metabolic diseases. We sought to determine the effects of hypoxia on maternal glucose and
Tumor metabolism, the ketogenic diet and β-hydroxybutyrate: novel approaches to adjuvant brain tumor therapy
Woolf E C, et al.
Frontiers in Molecular Neuroscience, 9, 122-122 (2016)
Jiang-Ping Song et al.
Science translational medicine, 12(530) (2020-02-14)
Sudden death could be the first symptom of patients with arrhythmogenic cardiomyopathy (AC), a disease for which clinical indicators predicting adverse progression remain lacking. Recent findings suggest that metabolic dysregulation is present in AC. We performed this study to identify
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