MAK041
β-Hydroxybutyrate Assay Kit
sufficient for 100 colorimetric tests
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.84
usage
sufficient for 100 colorimetric tests
detection method
colorimetric
relevant disease(s)
endocrinological disorders, diabetes; cancer; gastrointestinal diseases
storage temp.
−20°C
General description
β-Hydroxybutyrate, also known as 3-Hydroxy-butyrate, is a ketone body primarily synthesized in the liver from the oxidation of fatty acids. Ketone body formation, ketogenesis, is elevated when blood glucose levels drop. Moderately elevated blood ketone bodies occur normally during fasting and prolonged exercise. During alcoholic or diabetic ketoacidosis, blood levels of β-hydroxybutyrate can rise to abnormally high levels. β-hydroxybutyrate can be used as a marker for hepatic energy metabolism. β-hydroxybutyrate formation increases with excessive acetyl-CoA, and serves as a source of energy to the brain.
Application
β-Hydroxybutyrate Assay Kit has been used
- to quantify the level of β-hydroxybutyrate in plasma/serum
- to study the change in myocardial 18F-FDG uptake upon extended ketogenic diet, by measuring the level of plasma ketone bodies
- to study the role of β-hydroxybutyrate in the treatment of impairment and neuropathic pain in spinal cord-injured mice
Suitability
Suitable for the measurement β-Hydroxybutyrate levels in biological samples including serum and urine
Principle
In this assay, β-Hydroxybutyrate concentration is determined by a coupled enzyme reaction, which results in a colorimetric (450 nm) product, proportional to the β-Hydroxybutyrate present.
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Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Storage Class Code
8A - Combustible corrosive hazardous materials
Regulatory Information
监管及禁止进口产品
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Alexandra Clément et al.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 27(2), 612-618 (2018-08-22)
Short periods of fasting and/or low-carbohydrate diet have been proven beneficial for decreasing the myocardial uptake of 18F-fluorodeoxyglucose (18F-FDG) and enhancing the detection of inflammatory heart diseases by 18F-FDG positron emission tomography (PET). This study aimed at determining whether this
Johanna Karlsson et al.
Journal of dairy science, 103(10), 8922-8937 (2020-08-05)
Ruminants can produce meat and milk from fibrous feed and byproducts not suitable for human consumption. However, high-yielding dairy cows are generally fed a high proportion of cereal grain and pulses, which could be consumed directly by humans. If high
Adriana Lelis Carvalho et al.
Journal of cellular physiology, 233(2), 1585-1600 (2017-06-21)
There is a growing and alarming prevalence of obesity and the metabolic syndrome in type I diabetic patients (T1DM), particularly in adolescence. In general, low bone mass, higher fracture risk, and increased marrow adipose tissue (MAT) are features of diabetic
Jiao Qian et al.
British journal of pharmacology, 174(13), 1961-1971 (2017-03-21)
Spinal cord injury (SCI) leads to severe motor and sensory dysfunction and significantly reduces the quality of life. The aim of the present work was to investigate the effect of administration of exogenous D-β-hydroxybutyrate (DBHB) on functional recovery and neuropathic
A 1-week extension of a ketogenic diet provides a further decrease in myocardial 18 F-FDG uptake and a high detectability of myocarditis with FDG-PET.
Clement A, et al.
Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology, 1-7 (2018)
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