MAK033
ADP Colorimetric/Fluorometric Assay Kit
sufficient for 100 colorimetric or fluorometric tests
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UNSPSC Code:
12352200
NACRES:
NA.84
Recommended Products
usage
sufficient for 100 colorimetric or fluorometric tests
detection method
colorimetric
fluorometric
storage temp.
−20°C
General description
The new ADP Assay Kit, MAK518, is now available! Adenosine diphosphate (ADP) is a nucleoside diphosphate that plays a critical role in energy transfer reactions. ADP is produced from adenosine triphosphate (ATP) via the action of ATPases. ADP also plays a critical role in platelet function. ADP, stored in platelet-dense granules, is released upon platelet activation where it acts on purinergic receptors to mediate intracellular signaling and platelet aggregation. ADP is a key agonist involved in thrombosis and hemostasis.
Features and Benefits
Compatible with high-throughput handling systems.
Suitability
Suitable for the measuerement of ADP in a variety of biological samples including cell and tissue lysates
Principle
In this assay, ADP (adenosine diphosphate) concentration is determined by a coupled enzyme reaction, which results in a colorimetric (570 nm)/fluorometric (λex = 535/λem = 587 nm) product, proportional to the ADP present.
replaced by
Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
WGK
WGK 3
Flash Point(F)
188.6 °F
Flash Point(C)
87 °C
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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ADP is not an agonist at P2X1 receptors: evidence for separate receptors stimulated by ATP and ADP on human platelets.
Mahaut-Smith M P, et al.
British Journal of Pharmacology, 131(1), 108-114 (2000)
Multinuclear magnetic resonance spectroscopy studies of brain purines in major depression.
Renshaw P F, et al.
The American Journal of Psychiatry, 158(12), 2048-2055 (2001)
Jianmin Zhang et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 39(9), 1836-1848 (2018-04-17)
Neuronal preconditioning in vitro or in vivo with a stressful but non-lethal stimulus leads to new protein expression that mediates a profound neuroprotection against glutamate excitotoxicity and experimental stroke. The proteins that mediate neuroprotection are relatively unknown and under discovery.
Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs.
Foster C J, et al.
The Journal of Clinical Investigation, 107(12), 1591-1598 (2001)
Ana Luisa Palacios-Acedo et al.
Frontiers in oncology, 11, 704945-704945 (2021-10-01)
Platelet function can be modified by cancer cells to support tumor growth, causing alterations in the delicate hemostatic equilibrium. Cancer-cell and platelet interactions are one of the main pillars of Trousseau's syndrome: a paraneoplastic syndrome with recurring and migrating episodes
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