M9568
Anti-Muscarinic Acetylcholine Receptor M3 antibody produced in rabbit
affinity isolated antibody
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About This Item
MDL number:
UNSPSC Code:
12352203
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat
technique(s)
immunoblotting: 1:2,000 (using ECL on rat brain lysate.)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CHRM3(1131)
mouse ... Chrm3(12671)
rat ... Chrm3(24260)
General description
Muscarinic acetylcholine receptor M3 possesses a vestibule which is a part of a hydrophilic channel having a orthosteric binding site.
Specificity
Muscarinic acetylcholine receptor m3.
Immunogen
Synthetic peptide from the third extracellular loop of rat m3 (Accession P08483).
Biochem/physiol Actions
Muscarinic acetylcholine receptor M3 functions as a protectant in myocardial ischemia. It also has roles in smooth muscle contraction and glandular secretion. The receptor has a specific affinity for the Gq/11 family of G proteins.
Target description
Muscarinic Acetylcholine Receptor M3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Patricia C Borck et al.
Clinical and experimental pharmacology & physiology, 47(2), 286-293 (2019-10-21)
Here, we investigate the effects of exercise training on glucose- and cholinergic-induced insulin secretion in pancreatic islets from obese and lean rats. Male Wistar rats were treated with monosodium glutamate (MSG) for the first 5 days of life, while control (CON)
Andrew C Kruse et al.
Nature, 482(7386), 552-556 (2012-02-24)
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (M1-M5) share a high degree of sequence
Zhenyu Pan et al.
PloS one, 7(3), e32571-e32571 (2012-03-08)
The M(3) subtype of muscarinic acetylcholine receptors (M(3)-mAChR) plays a protective role in myocardial ischemia and microRNAs (miRNAs) participate in many cardiac pathophysiological processes, including ischemia-induced cardiac injury. However, the role of miRNAs in M(3)-mAChR mediated cardioprotection remains unexplored. The
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