M9066
Microsomes from Liver, Pooled
from rat(Sprague-Dawley), male
Synonym(s):
Liver microsome preparation
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
12161501
NACRES:
NA.47
Recommended Products
biological source
rat (Sprague-Dawley)
Quality Level
form
liquid
packaging
vial of ~10 mg
shipped in
dry ice
storage temp.
−70°C
Looking for similar products? Visit Product Comparison Guide
General description
Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).
Application
Microsomes from Liver, Pooled has been used in following studies:
- inhibition of microsomal lipid peroxidation.
- hydroxylation of isorhynchophylline (ISOR) in rats.
Biochem/physiol Actions
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.
Source of drug metabolizing enzymes, including cytochrome P-450.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
动植物源性产品
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Metabolism of isorhynchophylline in rats detected by LC-MS.
Wang W
J. Pharm. Pharm. Sci., 13(1), 27-37 (2010)
Xiaofei Zhang et al.
ACS chemical neuroscience, 8(9), 1937-1948 (2017-06-02)
Metabotropic glutamate 2 receptors (mGlu
Michele Gottardi et al.
Environmental toxicology and chemistry, 36(8), 2155-2166 (2017-02-02)
Two of the main classes of pesticides commonly used in agriculture are azole fungicides and pyrethroid insecticides. Because azoles have been shown to synergize the effect of pyrethroids, the effect of their mixture is of concern. The aim of the
Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties.
Vavrikova E
International Journal of Molecular Sciences, 17(6) (2016)
Gengyang Yuan et al.
Journal of medicinal chemistry, 63(20), 12060-12072 (2020-09-29)
Three benzimidazole derivatives (13-15) have been synthetized as potential positron emission tomography (PET) imaging ligands for mGluR2 in the brain. Of these compounds, 13 exhibits potent binding affinity (IC50 = 7.6 ± 0.9 nM), positive allosteric modulator (PAM) activity (EC50
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service