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Merck
CN

M8693

Melanotan II acetate salt

≥95% (HPLC), MC3-R/MC4-R melanocortin agonist, lyophilized solid

Synonym(s):

Ac-[Nle4Asp5D-Phe7Lys10]α-MSH-(4-10)-NH2

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About This Item

Empirical Formula (Hill Notation):
C50H69N15O9 · xC2H4O2
CAS Number:
121062-08-6
Molecular Weight:
1024.18 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD06795842

Key Documents

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Product Name

Melanotan II acetate salt, ≥95% (HPLC)

SMILES string

[nH]1cncc1C[C@@H]2NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC2=O)Cc5ccccc5)CCCN=C(N)N)Cc3c4c([nH]c3)cccc4)C(=O)N)NC(=O)[C@@H](NC(=O)C)CCCC

InChI

1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1

InChI key

JDKLPDJLXHXHNV-MFVUMRCOSA-N

assay

≥95% (HPLC)

form

lyophilized solid

color

white

solubility

H2O: soluble 5 mg/mL

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

Gene Information

human ... MC3R(4159), MC4R(4160)
mouse ... MC3R(17201), MC4R(17202)
rat ... MC3R(29310), MC4R(25635)

Related Categories

General description

Melanotan II induces melanogenesis and thus increases skin pigmentation. It is an analog of α-melanocyte stimulating hormone.

Application

Melanotan II acetate salt has been used to study its inhibitory effects on feeding and energy expenditure in rats.

Biochem/physiol Actions

Melanotan II is a MC3-R/MC4-R melanocortin agonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000527806
0000527806
0000517267
0000517267
0000232818

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Miia Kilpeläinen et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 77(1), 20-25 (2010-10-23)
Peptide molecules can improve the treatment of a number of pathological conditions, but due to their physicochemical properties, their delivery is very challenging. The study aim was to determine whether nanostructured porous silicon could sustain the release and prolong the
Rosacea 101: Includes the Rosacea Diet null
Zeng-You Ye et al.
Regulatory peptides, 166(1-3), 112-120 (2010-10-13)
Sympathetic nerve activity is increased in obesity-related hypertension. However, the central mechanisms involved in the increased sympathetic outflow remain unclear. The hypothalamic melanocortin system is important for regulating energy balance and sympathetic outflow. To understand the mechanisms by which the
John-Paul Baird et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 301(4), R1044-R1056 (2011-07-08)
Injections of the melanocortin 3/4 receptor (MCR) agonist melanotan II (MTII) to a variety of brain structures produces anorexia, suggesting distributed brain MCR control of food intake. We performed a detailed analysis of feeding behavior (licking microstructure analysis) after a
Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets
Jose K
Frontiers in Behavioral Neuroscience (2015)
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