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M8574

Sigma-Aldrich

D-(+)-Mannose

synthetic, ≥99% (GC)

Synonym(s):

D-Mannopyranose

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About This Item

Empirical Formula (Hill Notation):
C6H12O6
CAS Number:
3458-28-4
Molecular Weight:
180.16
Beilstein:
1564373
EC Number:
222-392-4
MDL number:
MFCD00064122
UNSPSC Code:
12352201
PubChem Substance ID:
329818064
NACRES:
NA.25
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biological source

synthetic

Assay

≥99% (GC)

form

powder

optical activity

[α]25/D 13.5 to 14.9 °, c = 4% (w/v) in water

technique(s)

gas chromatography (GC): suitable

color

white to off-white

mp

133-140 °C (lit.)

solubility

water: soluble 10 g/L at 20 °C

storage temp.

room temp

SMILES string

OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O

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biological source

synthetic

biological source

wood

biological source

-

biological source

plant (Spruce, Birch or Beech Wood, Glucose)

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

solubility

water: soluble 10 g/L at 20 °C

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

H2O: 0.1 g/mL, clear, colorless

solubility

H2O: 50 mg/mL

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

Application

D-(+)-Mannose, a C-2 epimer of D-glucose, is used in the formation of glycan structure and glycosylation.

Biochem/physiol Actions

Mannose, a six-carbon carbohydrate, is the C-2 epimer of glucose and a critical sugar for protein glycosylation. Mannose can also be utilized by the brain as an alternative energy source.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品
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    Certificates of Analysis (COA)

    Lot/Batch Number
    WXBF2552V
    WXBF4594V
    0000286368
    0000224081
    0000224081

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    Simone Torretta et al.
    Nature communications, 11(1), 6343-6343 (2020-12-15)
    D-mannose is a monosaccharide approximately a hundred times less abundant than glucose in human blood. Previous studies demonstrated that supraphysiological levels of D-mannose inhibit tumour growth and stimulate regulatory T cell differentiation. It is not known whether D-mannose metabolism affects
    Brett Shannon et al.
    Journal of immunology (Baltimore, Md. : 1950), 192(11), 5074-5082 (2014-04-25)
    HSV-2 infection is common and generally asymptomatic, but it is associated with increased HIV susceptibility and disease progression. This may relate to herpes-mediated changes in genital and systemic immunology. Cervical cytobrushes and blood were collected from HIV-uninfected African/Caribbean women in
    Charles D Murin et al.
    Journal of virology, 88(17), 10177-10188 (2014-06-27)
    The neutralizing anti-HIV-1 antibody 2G12 is of particular interest due to the sterilizing protection it provides from viral challenge in animal models. 2G12 is a unique, domain-exchanged antibody that binds exclusively to conserved N-linked glycans that form the high-mannose patch
    Ana Sofia Carvalho et al.
    Molecular & cellular proteomics : MCP, 13(12), 3294-3307 (2014-08-17)
    We investigated the molecular effects of glucosamine supplements, a popular and safe alternative to nonsteroidal anti-inflammatory drugs, for decreasing pain, inflammation, and maintaining healthy joints. Numerous studies have reported an array of molecular effects after glucosamine treatment. We questioned whether
    Varnica Khetrapal et al.
    Nucleic acids research, 43(13), e83-e83 (2015-03-25)
    Creation of defined genetic mutations is a powerful method for dissecting mechanisms of bacterial disease; however, many genetic tools are only developed for laboratory strains. We have designed a modular and general negative selection strategy based on inducible toxins that
    View All Related Papers

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