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Merck
CN

M7920

Minoxidil Sulfate

K+ channel opener, powder

Synonym(s):

U-58838

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About This Item

Empirical Formula (Hill Notation):
C9H15N5O4S
CAS Number:
83701-22-8
Molecular Weight:
289.31
UNSPSC Code:
12352107
PubChem Substance ID:
24897202
NACRES:
NA.77
MDL number:
MFCD06248907
Form:
powder
Quality level:
200

Key Documents

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Product Name

Minoxidil Sulfate,

SMILES string

Nc1cc(nc(N)[n+]1OS([O-])(=O)=O)N2CCCCC2

InChI

1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6H,1-5H2,(H4,10,11,12,15,16,17)

InChI key

OEOLOEUAGSPDLT-UHFFFAOYSA-N

form

powder

originator

Johnson & Johnson

storage temp.

−20°C

Quality Level

200

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Application

Minoxidil sulfate (MXS) has been used as a drug agent to study its effects on alopecia in corticotropin-releasing factor over-expressing (CRF-OE) mice. It has also been used as a positive control in an assay for the culturing of rat vibrissa follicles.

Biochem/physiol Actions

Minoxidil sulfate (MXS) is an endogenous derivative of minoxidil. It possesses greater aqueous solubility and is a potent vasodilator. MXS has the potential to treat androgenic alopecia or male baldness.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Active metabolite of minoxidil.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000516383
0000516381
0000516383
0000516381
0000488908

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Sang-Cheol Kim et al.
Archives of pharmacal research, 35(8), 1495-1503 (2012-09-04)
This study was conducted to evaluate the effect of Acanthopanax koreanum and acankoreoside J from A. koreanum on the promotion of hair growth. When immortalized rat vibrissa dermal papilla cells were treated with extract of A. koreanum leaves, the proliferation
G M Pacifici et al.
European journal of clinical pharmacology, 45(4), 337-341 (1993-01-01)
Minoxidil requires to be sulphated to exert its hypotensive effect. We report on interindividual variability in the rate of minoxidil sulphation in 118 specimens of human liver and in platelets obtained from 100 healthy subjects and 100 newborns. The frequency
U Russ et al.
British journal of pharmacology, 122(6), 1119-1126 (1997-12-24)
1. The ATP-sensitive K+ channel (KATP channel) in A10 cells, a cell line derived from rat thoracic aorta, was characterized by binding studies with the tritiated KATP channel opener, [3H]-P1075, and by electrophysiological techniques. 2. Saturation binding experiments gave a
R Diem et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(6), 2058-2066 (2001-03-14)
Tumor-necrosis-factor-alpha (TNF-alpha) prevented secondary death of retinal ganglion cells (RGCs) after axotomy of the optic nerve in vivo. This RGC rescue was confirmed in vitro in a mixed retinal culture model. In accordance with our previous findings, TNF-alpha decreased outward
Guilherme Martins Gelfuso et al.
Journal of microencapsulation, 28(7), 650-658 (2011-08-10)
Given the hypothesis that microparticles can penetrate the skin barrier along the transfollicular route, this work aimed to obtain and characterise chitosan microparticles loaded with minoxidil sulphate (MXS) and to study their ability to sustain the release of the drug
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