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Merck
CN

M7659

Myosin Heavy Chain from rabbit muscle

buffered aqueous glycerol solution

Synonym(s):

ATPase inactive whole chain myosin

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About This Item

CAS Number:
1638095-42-7
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD00131647

Key Documents

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Product Name

Myosin Heavy Chain from rabbit muscle, buffered aqueous glycerol solution

biological source

rabbit muscle

form

buffered aqueous glycerol solution

technique(s)

electrophoresis: suitable

UniProt accession no.

Q07003

foreign activity

ATPase Activity ≤0.01 units/mg protein

storage temp.

−20°C

Quality Level

200

Gene Information

rabbit ... PBV1SPCR2(100009284)

Application

Myosin Heavy Chain from rabbit muscle has been used:
  • in SDS analysis of myosin heavy chain (MHC) composition and content
  • for microinjection into the outflow of heart (blood serum) and the cephalic cavities (embryonic cerebrospinal fluid) of chick embryo
  • as a muscle protein, to study the role of ascorbate as a facilitator of glycogen storage in muscles

Biochem/physiol Actions

Molecular motor involved in the contraction of muscles.

General description

Myosin heavy chain (MHC) is a motor protein of muscle thick filaments. MHC regulates ultrastructural diversity of myofibrils.

Physical form

Solution in 50% glycerol containing 0.6 M KCl and 0.005 M potassium phosphate, pH 6.5

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000401512
SLBZ8240
0000401512
SLBZ8240
SLBS4240

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Myosin heavy chain isoforms regulate muscle function but not myofibril assembly.
Wells L, et al.
The Embo Journal, 15(17), 4454-4459 (1996)
Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse
Kemp JG, et al.
International journal of obesity (2005), 33(8), 831-831 (2009)
L Wells et al.
The EMBO journal, 15(17), 4454-4459 (1996-09-02)
Myosin heavy chain (MHC) is the motor protein of muscle thick filaments. Most organisms produce many muscle MHC isoforms with temporally and spatially regulated expression patterns. This suggests that isoforms of MHC have different characteristics necessary for defining specific muscle
I Morano
Journal of molecular medicine (Berlin, Germany), 77(7), 544-555 (1999-09-24)
Cardiac contraction is triggered by the cyclic interaction of the "molecular motor" protein myosin with the actin filament, consuming ATP as the energy source to produce tension or shortening. The myosin heavy chain (MHC) contains the actin- and ATP-binding sites
A blood-CSF barrier function controls embryonic CSF protein composition and homeostasis during early CNS development
Parvas M, et al.
Developmental Biology, 321(1), 51-63 (2008)
View All Related Papers

Articles

Myosin

Myosins are a family of ATP-dependent motor proteins. Myosin II is the major contractile protein involved in eukaryotic muscle contraction by “walking” along actin microfilaments of the sarcomere

肌球蛋白(Myosin)

肌球蛋白是ATP依赖性运动蛋白家族。肌球蛋白II是真核肌肉收缩的主要收缩蛋白，通过沿着肌动蛋白微丝“行走”参与肌肉收缩。

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