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M7659

Sigma-Aldrich

Myosin Heavy Chain from rabbit muscle

buffered aqueous glycerol solution

Synonym(s):

ATPase inactive whole chain myosin

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About This Item

CAS Number:
1638095-42-7
MDL number:
MFCD00131647
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

rabbit muscle

Quality Level

200

form

buffered aqueous glycerol solution

technique(s)

electrophoresis: suitable

UniProt accession no.

Q07003

foreign activity

ATPase Activity ≤0.01 units/mg protein

storage temp.

−20°C

Gene Information

rabbit ... PBV1SPCR2(100009284)

General description

Myosin heavy chain (MHC) is a motor protein of muscle thick filaments. MHC regulates ultrastructural diversity of myofibrils.

Application

Myosin Heavy Chain from rabbit muscle has been used:
  • in SDS analysis of myosin heavy chain (MHC) composition and content
  • for microinjection into the outflow of heart (blood serum) and the cephalic cavities (embryonic cerebrospinal fluid) of chick embryo
  • as a muscle protein, to study the role of ascorbate as a facilitator of glycogen storage in muscles

Biochem/physiol Actions

Molecular motor involved in the contraction of muscles.

Physical form

Solution in 50% glycerol containing 0.6 M KCl and 0.005 M potassium phosphate, pH 6.5

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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L Wells et al.
The EMBO journal, 15(17), 4454-4459 (1996-09-02)
Myosin heavy chain (MHC) is the motor protein of muscle thick filaments. Most organisms produce many muscle MHC isoforms with temporally and spatially regulated expression patterns. This suggests that isoforms of MHC have different characteristics necessary for defining specific muscle
Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse
Kemp JG, et al.
International journal of obesity (2005), 33(8), 831-831 (2009)
I Morano
Journal of molecular medicine (Berlin, Germany), 77(7), 544-555 (1999-09-24)
Cardiac contraction is triggered by the cyclic interaction of the "molecular motor" protein myosin with the actin filament, consuming ATP as the energy source to produce tension or shortening. The myosin heavy chain (MHC) contains the actin- and ATP-binding sites
A blood-CSF barrier function controls embryonic CSF protein composition and homeostasis during early CNS development
Parvas M, et al.
Developmental Biology, 321(1), 51-63 (2008)
Myosin heavy chain isoforms regulate muscle function but not myofibril assembly.
Wells L, et al.
The Embo Journal, 15(17), 4454-4459 (1996)
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Myosin

Myosins are a family of ATP-dependent motor proteins. Myosin II is the major contractile protein involved in eukaryotic muscle contraction by “walking” along actin microfilaments of the sarcomere

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