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M7648

Sigma-Aldrich

Anti-Myosin (Skeletal and Smooth) antibody produced in rabbit

whole antiserum

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About This Item

MDL number:
MFCD00162703
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

contains

15 mM sodium azide

species reactivity

animal, human

technique(s)

indirect immunofluorescence: 1:10 using cultured fibroblasts

UniProt accession no.

P35579
P35580

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MYH10(4628) , MYH9(4627) , MYL9(10398)

General description

Myosin is a 500 kD protein that interacts with actin in muscle and in non-muscle cells. It is characterized with two identical heavy chains (200 kD each) and four light chains (15-20 kD each). Myosin molecules consist of two major regions; the tail (rod) and head. These molecules aggregate into filaments through the tail region and interact with actin and ATP through the head region.

Specificity

Shows a pattern of staining along stress fibers of cultured human and animal fibroblasts.

Immunogen

whole myosin (heavy and light chains) from bovine uterus.

Application

Anti-Myosin (Skeletal and Smooth) antibody produced in rabbit has been used in indirect immunofluorescence labeling.

Biochem/physiol Actions

Myosin plays a vital role in neurosensory and cortical function, membrane vesicle trafficking and determinant partitioning. Myosins with actin-stimulated ATPase activity is essential for various cellular movements. Myosins I and V mediates vesicle translocation. Myosin II with a long rod like tail domain, assembles into a bipolar thick filament and facilitate muscle contraction.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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F Baluska et al.
Developmental biology, 227(2), 618-632 (2000-11-10)
Plant root hair formation is initiated when specialized elongating root epidermis cells (trichoblasts) assemble distinct domains at the plasma membrane/cell wall cell periphery complexes facing the root surface. These localities show accumulation of expansin and progressively transform into tip-growing root
Myosin: The Actin Motor Protein
Molecular Cell Biology, 10(1), 80-86 (2000)
Root hair formation: F-actin-dependent tip growth is initiated by local assembly of profilin-supported F-actin meshworks accumulated within expansin-enriched bulges
Baluska F, et al.
Developmental Biology, 227(2), 618-632 (2000)
Myosins: matching functions with motors.
Baker JP and Titus MA.
Current Opinion in Cell Biology, 10(1), 80-86 (1998)
The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions?a novel architectonic cell-cell junction system
Domke LM and Franke WW
Cell and Tissue Research, 375(2), 451-482 (2019)
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