Skip to Content
Merck
CN

M6524

Methoxamine hydrochloride

α1-adrenoceptor agonist

Synonym(s):

α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C11H17NO3 · HCl
CAS Number:
61-16-5
Molecular Weight:
247.72
NACRES:
NA.77
PubChem Substance ID:
24277785
UNSPSC Code:
12352116
EC Number:
200-499-7
MDL number:
MFCD00058607

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Methoxamine hydrochloride,

InChI key

YGRFXPCHZBRUKP-UHFFFAOYSA-N

InChI

1S/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H

SMILES string

Cl[H].COc1ccc(OC)c(c1)C(O)C(C)N

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Related Categories

Biochem/physiol Actions

α1-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000526209
0000526209
0000515863
0000515863
0000434852

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Sven Francque et al.
Laboratory investigation; a journal of technical methods and pathology, 92(10), 1428-1439 (2012-08-15)
Non-alcoholic fatty liver disease can progress to steatohepatitis and fibrosis, and is also associated with impaired liver regeneration. The pathophysiology remains elusive. We recently showed that severe steatosis is associated with an increase in portal pressure, suggesting liver flow impairment.
Robert H Thiele et al.
Anesthesia and analgesia, 113(2), 284-296 (2011-04-27)
Phenylephrine and methoxamine are direct-acting, predominantly α(1) adrenergic receptor (AR) agonists. To better understand their physiologic effects, we screened 463 articles on the basis of PubMed searches of "methoxamine" and "phenylephrine" (limited to human, randomized studies published in English), as
L Nalos et al.
British journal of pharmacology, 165(2), 467-478 (2011-07-02)
Drug development requires the testing of new chemical entities for adverse effects. For cardiac safety screening, improved assays are urgently needed. Isolated adult cardiomyocytes (CM) and human embryonic stem cell-derived cardiomyocytes (hESC-CM) could be used to identify pro-arrhythmic compounds. In
Chandana B Herath et al.
American journal of physiology. Gastrointestinal and liver physiology, 304(1), G99-108 (2012-10-23)
Recent studies have shown that, in cirrhosis, portal angiotensin-(1-7) [Ang-(1-7)] levels are increased and hepatic expression of angiotensin converting enzyme 2 (ACE2) and the Mas receptor are upregulated, but the effects of Ang-(1-7) on hepatic hemodynamics in cirrhosis have not
Linard Filli et al.
Brain : a journal of neurology, 134(Pt 8), 2261-2273 (2011-07-15)
Cervical incomplete spinal cord injuries often lead to severe and persistent impairments of sensorimotor functions and are clinically the most frequent type of spinal cord injury. Understanding the motor impairments and the possible functional recovery of upper and lower extremities
View All Related Papers

Articles

α1-Adrenoceptor Characteristics and Modulators

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service