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M5824

Sigma-Aldrich

MBX-102 acid

≥98% (HPLC), powder

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Synonym(s):
(aR)-4-chloro-a-[3-(trifluoromethyl)phenoxy]benzeneacetic acid, MBX-102/JNJ39659100
Empirical Formula (Hill Notation):
C15H10ClF3O3
CAS Number:
23953-39-1
Molecular Weight:
330.69
MDL number:
MFCD19686974
UNSPSC Code:
12352202
PubChem Substance ID:
329818023
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥20 mg/mL

originator

Johnson & Johnson

storage temp.

2-8°C

SMILES string

OC(=O)[C@H](Oc1cccc(c1)C(F)(F)F)c2ccc(Cl)cc2

InChI

1S/C15H10ClF3O3/c16-11-6-4-9(5-7-11)13(14(20)21)22-12-3-1-2-10(8-12)15(17,18)19/h1-8,13H,(H,20,21)/t13-/m1/s1

InChI key

DDTQLPXXNHLBAB-CYBMUJFWSA-N

Biochem/physiol Actions

MBX-102 is a selective PPAR modulator (SPPARM) and has been shown to inhibit phosphorylation of PPARγ.

Features and Benefits

This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H301,H410

Precautionary Statements

P273 - P301 + P310 - P501

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

WGK

WGK 3

Regulatory Information

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Articles

Nuclear Receptors: PPARs

Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors related to hormone receptors, influencing gene expression.

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