M4632
2-Chloro-5,5-dimethyl-1,3-cyclohexanedione
Synonym(s):
2-Chlorodimedone
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About This Item
Empirical Formula (Hill Notation):
C8H11ClO2
CAS Number:
Molecular Weight:
174.62
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
Beilstein/REAXYS Number:
2326749
SMILES string
CC1(C)CC(=O)C(Cl)C(=O)C1
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
161-164 °C (lit.)
format
neat
storage temp.
−20°C
General description
Substrate for chloroperoxidase.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Z S Farhangrazi et al.
Biochemistry, 31(44), 10763-10768 (1992-11-10)
Monochlorodimedone (MCD), commonly used as a halogen acceptor for haloperoxidase assays, was oxidized by hydrogen peroxide in the presence of lignin peroxidase isoenzymes H2 and H8. When oxidized, it produced a weak absorption band with an intensity that varied with
Stimulation of the chlorinating activity of human myeloperoxidase by thyroid hormones and analogues.
J M Van Zyl et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 21(8), 441-444 (1989-08-01)
Thyroxine and triiodothyronine concentrations of 50 nM or lower can stimulate the chlorinating activity of the myeloperoxidase-H2O2-Cl- antimicrobial system in vitro. The initial rates of the chlorinating reaction with monochlorodimedone were similar for both thyroid hormones. Maximum stimulation occurred around
K W Zuurbier et al.
Biochimica et biophysica acta, 1037(2), 140-146 (1990-02-09)
The steady-state activity of myeloperoxidase in the chlorination of monochlorodimedone at neutral pH was investigated. Using a stopped-flow spectrophotometer we were able to show that the enzymic activity at pH 7.2 rapidly declined in time. During the first 50-100 ms
P Barnett et al.
The Journal of biological chemistry, 273(36), 23381-23387 (1998-08-29)
Here we describe the isolation, purification, and basic kinetic parameters of a vanadium type chloroperoxidase from the hyphomycete fungus Embellisia didymospora. The enzyme proved to possess similar high substrate affinities, a Km of 5 microM for a bromide, 1.2 mM
Tina Kirchner et al.
Archives of biochemistry and biophysics, 495(1), 21-27 (2009-12-19)
The heme-containing enzyme myeloperoxidase (MPO) accumulates at inflammatory sites and is able to catalyse one- and two-electron oxidation reactions. Here it is shown that (-)-epicatechin, which is known to have numerous beneficial health effects, in low micromolar concentration enhances the
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