M4154
β-N-Methylamino-L-alanine hydrochloride
Synonym(s):
L-BMAA
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About This Item
Empirical Formula (Hill Notation):
C4H10N2O2 · HCl
CAS Number:
Molecular Weight:
154.60
UNSPSC Code:
12352200
MDL number:
SMILES string
CNCC(N)C(O)=O
storage temp.
2-8°C
Biochem/physiol Actions
Neuroexcitotoxic amino acid; may be involved in Guam amyotrophic lateral sclerosis
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Oliver Okle et al.
Toxicology and applied pharmacology, 270(1), 9-15 (2013-04-18)
The cyanobacterially produced neurotoxin beta-N-methylamino-l-alanine (BMAA) is thought to induce amyotrophic lateral sclerosis/Parkinsonism dementia complex (ALS/PDC)-like symptoms. However, its mechanism of action and its pathway of intoxication are yet unknown. In vivo animal models suitable for investigating the neurotoxic effect
Elisabeth J Faassen et al.
PloS one, 7(5), e36667-e36667 (2012-05-10)
The cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) has been considered a serious health threat because of its putative role in multiple neurodegenerative diseases. First reports on BMAA concentrations in cyanobacteria were alarming: nearly all cyanobacteria were assumed to contain high BMAA concentrations
Steven A Cohen
The Analyst, 137(9), 1991-2005 (2012-03-17)
The non-protein amino acid L-α-amino-β-methylaminopropionic acid (BMAA) has been linked to several neurodegenerative diseases. Its presence in trace amounts in complex sample such as bacterial, plant and mammalian tissue extracts and hydrolyzates makes analysis a complicated process requiring good analytical
Estefanía de Munck et al.
Environmental toxicology and pharmacology, 35(2), 193-199 (2013-01-19)
β-N-methylamino-(L)-alanine (L)-BMAA) is a neurotoxic amino acid, found in the majority of cyanbacterial genera tested. Evidence for implication of (L)-BMAA in neurodegenerative disorders, like amyotrophic lateral sclerosis (ALS), relies on bioaccumulation and biomagnification from symbiotic cyanobacteria. The involvement of (L)-BMAA
Elijah W Stommel et al.
Medical hypotheses, 80(2), 142-145 (2012-12-19)
Sporadic amyotrophic lateral sclerosis (sALS) is a fatal neurodegenerative disease with no known cause. There are many clues to suggest an environmental trigger for the disease, including reports of conjugal couples and co-localized employees that developed sALS. On the island
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