M3787
Anti-MAP Kinase Phosphatase-1 (MKP-1) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
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About This Item
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biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 39 kDa
species reactivity
human
technique(s)
microarray: suitable
western blot: 1:5,000 using TPA-induced A431 whole cell extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... DUSP1(1843)
mouse ... Dusp1(19252)
General description
Map kinase phosphatase-1 (MKP-1) is a protein that belongs to protein-tyrosine phosphatase family. It has a pivotal role in inhibiting p38 and subsequent destabilisation of pro-inflammatory mRNAs by GCs. It also has a crucial role in regulating MAP kinase and can inhibit fibroblast proliferation due to overexpression. Anti-MAP kinase phosphatase-1 (MKP-1) antibody can be used to study the differential tissue expression, specific activation requirements and for intracellular localization of MAP kinase phosphatases in normal and neoplastic cells and tissues. Rabbit anti-MAP kinase phosphatase-1 (MKP-1) antibody reacts specifically with MAP kinase phosphatase-1 (39 kD protein). The product has also shown reactivity for human.
Immunogen
Synthetic peptide corresponding to amino acids 87-99 of mouse MAP kinase phosphatase-1, coupled to KLH.
Application
Anti-MAP kinase phosphatase-1 (MKP-1) antibody can be used in western blotting (diluted-1:5,000) using TPA-induced A431 whole cell extract. It can also be used in microarray.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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H Sun et al.
Science (New York, N.Y.), 266(5183), 285-288 (1994-10-14)
Mitogen-activated protein kinases (MAP kinases) are common components of signaling pathways induced by diverse growth stimuli. Although the guanidine nucleotide-binding Ras proteins are known to be upstream activators of MAP kinases, the extent to which MAP kinases directly contribute to
A R Clark
The Journal of endocrinology, 178(1), 5-12 (2003-07-08)
Synthetic glucocorticoids (GCs) potently inhibit the expression of pro-inflammatory genes and are widely used in the treatment of inflammatory diseases. However, some patients are resistant to the therapeutic effects of GCs, and many suffer deleterious side effects from these drugs.
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