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Merck
CN

M3781

6α-Methylprednisolone 21-hemisuccinate sodium salt

synthetic, ≥98.00% (TLC), Prednisolone derivative, lyophilized powder

Synonym(s):

6α-Methylprednisolone sodium succinate, MPSL, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate

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About This Item

Linear Formula:
C26H33O8Na
CAS Number:
2375-03-3
Molecular Weight:
496.53
NACRES:
NA.77
PubChem Substance ID:
24896873
UNSPSC Code:
51111800
EC Number:
219-156-8
MDL number:
MFCD00152612

Key Documents

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Product Name

6α-Methylprednisolone 21-hemisuccinate sodium salt, lyophilized powder

InChI

1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1

InChI key

FQISKWAFAHGMGT-SGJOWKDISA-M

SMILES string

[Na+].C[C@H]1CC2C3CC[C@](O)(C(=O)COC(=O)CCC([O-])=O)[C@@]3(C)C[C@H](O)C2[C@@]4(C)C=CC(=O)C=C14

biological source

synthetic

sterility

non-sterile

assay

≥98.00% (TLC)

form

lyophilized powder

technique(s)

toxicology assay: suitable

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

Quality Level

100

Gene Information

human ... NR3C1(2908)

Related Categories

Application

6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.

Biochem/physiol Actions

Glucocorticoid with slightly longer half-life than that of prednisolone.

Physical form

Lyophilized containing ~5% phosphate buffer salts.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H351,H360

Hazard Classifications

Carc. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN5669
BCCG3096
BCBZ8796
BCBW7102
SLBG7439V

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Rina Ulmansky et al.
Journal of controlled release : official journal of the Controlled Release Society, 160(2), 299-305 (2012-01-10)
We have previously shown that intravenous (i.v.) treatment with sterically stabilized nano-liposomes (NSSL) actively remote-loaded with the glucocorticoid (GC) methylprednisolone hemisuccinate (NSSL-MPS) or betamethasone hemisuccinate (NSSL-BMS) significantly decreased severity of adjuvant arthritis in Lewis rats (a model of human rheumatoid
Dapsone hypersensitivity syndrome complicated by Scedosporium apiospermum pneumonia in an immunocompetent patient.
L Ceccarelli et al.
Infection, 40(4), 459-462 (2011-11-30)
Julie M Jones et al.
The Journal of the American Osteopathic Association, 112(2), 90-92 (2012-02-15)
Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a type III hypersensitivity reaction characterized by urticaria with persistent acquired hypocomplementemia. Although HUVS is uncommon, it is important for physicians to be familiar with this disease, as the initial presentation is often life-threatening
[The issue of methylprednisolone sodium succinate dosage for use].
Yu-cai Zhang et al.
Zhonghua er ke za zhi = Chinese journal of pediatrics, 49(5), 389-390 (2011-06-01)
Localized skin necrosis of steroid-induced striae distensae: an unusual complication of bevacizumab and irinotecan therapy.
Sabrina Fourcade et al.
Archives of dermatology, 147(10), 1227-1228 (2011-10-19)
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