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Merck
CN

M3199

MK-212 hydrochloride

≥98% (HPLC)

Synonym(s):

2-Chloro-6-(1-piperazinyl)-pyrazine hydrochloride, 6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride, NSC 31732

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About This Item

Empirical Formula (Hill Notation):
C8H11ClN4·HCl
CAS Number:
61655-58-1
Molecular Weight:
235.11
NACRES:
NA.77
PubChem Substance ID:
329817966
UNSPSC Code:
12352200
EC Number:
262-883-0
MDL number:
MFCD00673963

Key Documents

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form

powder

InChI

1S/C8H11ClN4.ClH/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13;/h5-6,10H,1-4H2;1H

InChI key

PFIZGLUIYAZQFU-UHFFFAOYSA-N

SMILES string

Cl.Clc1cncc(n1)N2CCNCC2

assay

≥98% (HPLC)

storage condition

desiccated

color

white to off-white

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Selective 5-HT2C serotonin receptor agonist.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
080M4602

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Julie D Ross et al.
Drug and alcohol dependence, 81(2), 117-127 (2005-08-02)
3,4-Methylenedioxymethamphetamine [MDMA; ecstasy] evokes a multifaceted subjective experience in human users which includes stimulation, feelings of well-being, mood elevation, empathy towards others as well as distortions in time, sensation and perception. Aspects of this unique psychopharmacology of MDMA are thought
Laura M Hurley
Journal of neurophysiology, 96(5), 2177-2188 (2006-07-28)
The neuromodulator serotonin has a complex set of effects on the auditory responses of neurons within the inferior colliculus (IC), a midbrain auditory nucleus that integrates a wide range of inputs from auditory and nonauditory sources. To determine whether activation
Kunihiro Nakai et al.
European journal of pain (London, England), 14(10), 999-1006 (2010-05-22)
Peripheral branches of the trigeminal nerve may be damaged during maxillofacial injury or surgical procedures and trigeminal trauma may induce severe pain that is very challenging to treat. Chronic constriction injury to the infraorbital nerve (ION-CCI) by loose ligatures has
M-A Comet et al.
The European journal of neuroscience, 26(2), 345-354 (2007-07-12)
Our first aim was to elucidate the mechanisms underlying the hypotensive response elicited by 5-HT(2) receptor activation in the nucleus tractus solitarius (NTS). In pentobarbitone-anaesthetized rats, intra-NTS administration of 2,5-dimethoxy-4-iodoamphetamine (DOI), a wide spectrum 5-HT(2) receptor agonist, but not an
Ellen A Walker et al.
Neuropharmacology, 49(8), 1210-1219 (2005-09-17)
Serotonin(2C) (5-HT(2C)) receptors have been implicated to treat mood disorders such as depression and anxiety. In the present study, the capacities of two 5-HT(2C) agonists, MK212 and mCPP, to produce conditioned taste aversions in mice were evaluated. On two training
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