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M2692

Sigma-Aldrich

MK-886 sodium salt hydrate

>98% (HPLC)

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Synonym(s):
3-[3-tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid, sodium salt hydrate
Empirical Formula (Hill Notation):
C27H33NO2ClSNa · xH2O
CAS Number:
Molecular Weight:
494.06 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

Assay

>98% (HPLC)

color

white

solubility

DMSO: 32 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

O.[Na+].CC(C)c1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)C([O-])=O)c(SC(C)(C)C)c2c1

InChI

1S/C27H34ClNO2S.Na.H2O/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18;;/h8-14,17H,15-16H2,1-7H3,(H,30,31);;1H2/q;+1;/p-1

InChI key

APMAGPLTTCSTMM-UHFFFAOYSA-M

Biochem/physiol Actions

Potent and specific inhibitor of leukotriene biosynthesis.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Chen-Hsuan Wang et al.
Brain research bulletin, 79(3-4), 169-176 (2009-05-12)
Molecules involved in self-protection of neurons against glucose/oxygen/serum deprivation (GOSD) were investigated. Trypan blue dye exclusion assay, Western blotting, ELISA, cytokine antibody array and chemical blocking assay were applied in the study. Results showed that early induction (at 6h of

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