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Merck
CN

M2525

Mianserin hydrochloride

5-HT2 serotonin receptor

Synonym(s):

1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H20N2 · HCl
CAS Number:
21535-47-7
Molecular Weight:
300.83
NACRES:
NA.77
PubChem Substance ID:
24278125
UNSPSC Code:
12352200
EC Number:
244-426-7
MDL number:
MFCD00055072

Key Documents

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Product Name

Mianserin hydrochloride,

InChI key

YNPFMWCWRVTGKJ-UHFFFAOYSA-N

InChI

1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H

SMILES string

Cl.CN1CCN2C(C1)c3ccccc3Cc4ccccc24

solubility

H2O: 3.4 mg/mL
ethanol: 5.6 mg/mL

originator

Organon

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), HRH1(3269), HTR2A(3356), HTR2B(3357), HTR2C(3358)

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Application

Mianserin hydrochloride has been used:
  • as a reversible antagonist for serotonergic -protein coupled receptor (GPCR) - G-protein protein-coupled receptor (S7.1R)
  • as an antidepressant in hippocampal astrocytes to test its effect on brain-derived neurotrophic factor (BDNF) mRNA expression
  • as a 5-hydroxytryptamine (5-HT) receptor antagonist to study its effect on serotonin modulation

Biochem/physiol Actions

Antidepressant; antagonist/inverse agonist at 5-HT2 serotonin receptors; also blocks the H1 histamine receptor and the α2 adrenoceptor.
Mianserin is a tetracyclic compound with sedative property. It lacks anticholinergic activity and is not effective on serotoninergic mechanisms. Mianserin is eliminated post biotransformation as hydroxylation, N-oxidation and N-demethylation products.

Features and Benefits

This compound was developed by Organon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Solutions may be stored for several days at 4°C.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000456410
0000456409
0000456402
0000456409
0000456410

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D L Willins et al.
Neuroscience, 91(2), 599-606 (1999-06-12)
In this study, we demonstrate that clozapine and other atypical antipsychotic drugs induce a paradoxical internalization of 5-hydroxytryptamine-2A receptors in vitro and a redistribution of 5-hydroxytryptamine-2A receptors in vivo. We discovered that clozapine, olanzapine, risperidone and the putative atypical antipsychotic
Anti-depressant fluoxetine reveals its therapeutic effect via astrocytes
Kinoshita M, et al.
EBioMedicine, 32(3), 72-83 (2018)
Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness
Brogden RN, et al.
Drugs, 16(4), 273-301 (1978)
P A Lavoie et al.
European journal of pharmacology, 369(3), 387-390 (1999-05-04)
In order to test potential links with other stereospecific neurobiological effects of mianserin, the present study explored the stereospecificity for inhibition of depolarization-induced Ca2+ uptake by mianserin. Synaptosomes from rat hippocampus were incubated with 45Ca2+ in either resting or depolarizing
I M Leitch et al.
The Journal of pharmacy and pharmacology, 44(4), 315-320 (1992-04-01)
Some in-vitro pharmacological effects of a novel analogue of mianserin, 2-carboxamidino-1,2,3,4,10,14b-hexahydrodibenzo (c,f) pyrazino (1,2-alpha) azepine hydrochloride (FCC5) have been studied. FCC5 was a non-competitive antagonist of both histamine-induced contractions of the guinea-pig ileum and 5-HT-induced contractions of rat fundal strips
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