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M1818

Sigma-Aldrich

Molindone hydrochloride

≥98% (HPLC), solid

Synonym(s):

3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H24N2O2 · HCl
CAS Number:
Molecular Weight:
312.83
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

Quality Level

Assay

≥98% (HPLC)

form

solid

color

off-white

solubility

H2O: 19 mg/mL

originator

Endo

SMILES string

CCC1=C(C)NC2=C1C(C(CN3CCOCC3)CC2)=O.Cl

InChI

1S/C16H24N2O2.ClH/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18;/h12,17H,3-10H2,1-2H3;1H

InChI key

GQWNECFJGBQMBO-UHFFFAOYSA-N

Gene Information

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Biochem/physiol Actions

D2 dopamine receptor antagonist; MAO inhibitor.

Features and Benefits

This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Aripiprazole-induced agitation after clozapine discontinuation: a case report.
Dara Y Cho et al.
The Journal of clinical psychiatry, 70(1), 141-143 (2009-02-19)
Robert L Findling et al.
Journal of the American Academy of Child and Adolescent Psychiatry, 49(6), 583-594 (2010-05-25)
To examine the long-term safety and efficacy of three antipsychotics in early-onset schizophrenia spectrum disorders. Patients (8 to 19 years old) who had improved during an 8-week, randomized, double-blind acute trial of olanzapine, risperidone, or molindone (plus benztropine) were eligible
H B Pinkofsky
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 9(3), 175-179 (1997-10-27)
The onset of psychosis during pregnancy presents several difficult management decisions and a careful risk-benefit analysis is required. Withholding antipsychotic treatment may produce more risks than benefits. Studies on neuroleptic teratogenicity are contradictory. Most of the commonly used neuroleptics exhibit
R B Rosse et al.
Clinical neuropharmacology, 19(5), 444-450 (1996-10-01)
This preliminary investigation examined the therapeutic efficacy of two doses of oral D-cycloserine (5 and 15 mg p.o. b.i.d.) administered as an adjuvant to molindone (150 mg p.o. q.d.) in the treatment of schizophrenia. D-Cycloserine is an agonist at the
Jon McClellan et al.
Journal of the American Academy of Child and Adolescent Psychiatry, 46(8), 969-978 (2007-08-02)
The Treatment of Early Onset Schizophrenia Spectrum Disorders Study is a publicly funded clinical trial designed to compare the therapeutic benefits, safety, and tolerability of risperidone, olanzapine, and molindone in youths with early-onset schizophrenia spectrum disorders. The rationale, design, and

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