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M1778

Sigma-Aldrich

Mucin from porcine stomach

Type III, bound sialic acid 0.5-1.5 %, partially purified powder

Synonym(s):

MUC

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About This Item

CAS Number:
84082-64-4
EC Number:
282-010-7
MDL number:
MFCD00131629
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

Porcine stomach

Quality Level

200

type

Type III

form

partially purified powder

composition

bound sialic acid, 0.5-1.5%

technique(s)

microbiological culture: suitable

solubility

NaOH: soluble 20 mg/mL

storage temp.

2-8°C

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General description

Mucins or mucus glycoproteins are the main macromolecular components of mammalian mucus. It was also used in a study to evaluate the sputum smears concentrated by cyto-centrifugation for detection of acid-fast bacilli.

Application

Mucin from porcine stomach was used in studies on the binding site of the galactose-specific agglutinin PA-IL from Pseudomonas aeruginosa.

Biochem/physiol Actions

Mucus forms the protective cover for all epithelial surfaces. The major structural component of mucus is gel-forming mucins. The mucus layer covering the intestinal epithelium has the MUC2 mucin as its central molecule. MUC2 is produced by goblet cells.

Preparation Note

Prepared according to the method of Glenister, et al., for use in complex growth media for dental plaque bacteria.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

动植物源性产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000386654
0000380455
0000368380
0000368381
0000364235

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What does the "Type" designation in Mucin from porcine stomach mean?

    The type designation does not have any particular biological significance.  It is used to emphasize differences in the listings of this product.

  6. Is Product M1778, Mucin from porcine stomach, a purified preparation of mucin?

    This product is a partially purified preparation of mucin based on the method of Glenister cited on the product's webpage.

  7. How can I solubilize Product M1778, Mucin from porcine stomach?

    Mucin is not readily soluble in aqueous solutions. Turbid "solutions" will form at about 5 mg/mL in 0.1 M acetate buffer, pH 5.0. To try to increase the solubility, one might try further dilution and sonication, but we have not tried this in our labs.

  8. What is the molecular weight of Product M1778, Mucin from porcine stomach?

    This product is partially purified from crude mucin, M2378.  Sigma has not determined the molecular weight of this product. Neither has the sugar and amino acid composition been determined.

  9. What are the differences between Mucin from porcine stomach Products M2378 and M1778?

    Product No. M2378 is a crude mucin preparation. Product No. M1778 is a partially purified powder prepared according to the method described in Glenister, D.A. and Salmon. K. Microbial Ecol. in Health & Disease 1, 31, (1988). The amount of bound sialic acids are also different. Please refer to the specification sheets on our website.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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