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Merck
CN

M1636

Myosin, Calcium activated from rabbit muscle

buffered aqueous glycerol solution, 0.5-1.5 units/mg protein (biuret)

Synonym(s):

Myosin adenosinetriphosphatase

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD00131645

Key Documents

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Product Name

Myosin, Calcium activated from rabbit muscle, buffered aqueous glycerol solution, 0.5-1.5 units/mg protein (biuret)

biological source

rabbit muscle

form

buffered aqueous glycerol solution

specific activity

0.5-1.5 units/mg protein (biuret)

mol wt

heavy chain ~200 kDa (each)
light chain 15-20 kDa (each)
 ~480 kDa

technique(s)

ELISA: suitable

shipped in

wet ice

storage temp.

−20°C

Quality Level

200

Biochem/physiol Actions

Interacts with actin in muscle and non-muscle cells; involved in neurosensory function, vesicle trafficking, determinant partitioning, and cortical function.
Myosin interacts with actin in muscle and non-muscle cells. Myosin molecules consist of two major regions: tails (rods) and heads. They aggregate into filaments through the tail region and interact with actin and with ATP through the head region. Myosin molecules spontaneously assemble into filaments in solutions of physiologic ionic strength and pH. Thick filament consists mainly of myosin molecules. Myosin is activated by the enzyme ATPase. This activation is the immediate source of the free energy that drives muscle contraction. It binds to the polymerized form of actin, the major constituent of the thin filament. Multiple forms of myosin heavy chains exist for each muscle type-skeletal, cardiac, smooth and non-muscle isomyosin forms exist in different types of skeletal muscle, depending on the physiological function of the muscle. These are designated as type I (slow-twitch) and type II (fast-twitch). Myosin is one of three classes of cytoskeletal motor proteins that have been identified. The others are kinesins and dyneins. These three types of proteins are thought to be responsible for the many movements that occur in cells. Myosin has been shown to be involved in neurosensory function, vesicle trafficking, determinant partitioning, and cortical function.
Myosin interacts with actin in muscle and non-muscle cells. Myosin is one of three classes of cytoskeletal motor proteins that have been identified. The others are kinesins and dyneins. These three types of proteins are thought to be responsible for the many movements that occur in cells. Myosin has been shown to be involved in neurosensory function, vesicle trafficking, determinant partitioning, and cortical function.

Other Notes

One unit will liberate 1.0 μmole of inorganic phosphorus from ATP per min at pH 9.0 at 25 °C in the presence of calcium.

Physical form

Solution in 50% glycerol containing 0.6 M potassium chloride and 10 mM potassium phosphate buffer, pH 6.8. Note: Solution may be hazy.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

低风险生物材料
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Certificates of Analysis (COA)

Lot/Batch Number
0000498756
0000498754
0000498755
0000498755
0000498754

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Lichuang Cao et al.
Food chemistry, 356, 129655-129655 (2021-04-09)
Phosphorylation of myosin regulatory light chain (MRLC) can regulate muscle contraction and thus affect actomyosin dissociation and meat quality. The objective of this study was to explore the mechanism by how MRLC phosphorylation regulates actomyosin dissociation and thus develop strategies
Brandon M Hoover et al.
Journal of pharmaceutical sciences, 109(1), 452-463 (2019-10-12)
Nanoparticle tracking analysis (NTA) is an important technique for measuring hydrodynamic size of globular biological particles including liposomes and viruses. Less attention has been paid to NTA of rod-like particles, despite their considerable interest. For example, amyloid fibrils and protofibrils
Juan Chen et al.
Experimental and therapeutic medicine, 14(3), 2085-2093 (2017-10-01)
3-
E Bischoff et al.
Molecular microbiology, 35(5), 1005-1016 (2000-03-11)
Four large multigene families have been described in Plasmodium falciparum malaria parasites (var, rif, stevor and Pf60). var and rif genes code for erythrocyte surface proteins and undergo clonal antigenic variation. We report here the characterization of the first Pf60
Beata Brozek-Pluska et al.
International journal of molecular sciences, 20(14) (2019-07-13)
Noninvasive Raman imaging of non-fixed and unstained human colon tissues based on vibrational properties of noncancerous and cancerous samples can effectively enable the differentiation between noncancerous and tumor tissues. This work aimed to evaluate the biochemical characteristics of colon cancer

Articles

Myosin

Myosins are a family of ATP-dependent motor proteins. Myosin II is the major contractile protein involved in eukaryotic muscle contraction by “walking” along actin microfilaments of the sarcomere

肌球蛋白(Myosin)

肌球蛋白是ATP依赖性运动蛋白家族。肌球蛋白II是真核肌肉收缩的主要收缩蛋白，通过沿着肌动蛋白微丝“行走”参与肌肉收缩。

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