M1508
4-Methylumbelliferone sodium salt
≥98% (HPLC), crystalline
Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
β-Methylumbelliferone, 7-Hydroxy-4-methylcoumarin
Linear Formula:
C10H7O3Na
CAS Number:
Molecular Weight:
198.15
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
crystalline
color
yellow
solubility
water: 50 mg/mL
SMILES string
[Na+].CC1=CC(=O)Oc2cc([O-])ccc12
InChI
1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
InChI key
JGMQHDNPUCPRQE-UHFFFAOYSA-M
Related Categories
General description
4-methylumbelliferone (4-MU) is a coumarin derivative.
Application
4-Methylumbelliferone sodium salt has been used:
- as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liver
- as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action
- in cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer
Biochem/physiol Actions
4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic, and antitumor properties. 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response. 4-MU is known to be glucuronidated by most of the uridine 5ฺ-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Ai-Sheng Xiong et al.
PloS one, 6(11), e26773-e26773 (2011-11-19)
A β-glucuronidase variant, GUS-TR3337, that was obtained by directed evolution exhibited higher thermostability than the wild-type enzyme, GUS-WT. In this study, the utility of GUS-TR337 as an improved reporter was evaluated. The corresponding gus-tr3337 and gus-wt genes were independently cloned
Gale E Smith et al.
Virology, 509, 90-97 (2017-06-19)
Avian influenza A (H5N1) viruses represent a growing threat for an influenza pandemic. The presence of widespread avian influenza virus infections further emphasizes the need for vaccine strategies for control of pre-pandemic H5N1 and other avian influenza subtypes. Influenza neuraminidase
Matías A Pibuel et al.
Glycobiology, 31(1), 29-43 (2020-05-31)
Glioblastoma (GBM), the most frequent primary tumor of the central nervous system, has a median survival of 14.6 months. 4-Methylumbelliferone (4MU) is a coumarin derivative widely used as a hyaluronan synthesis inhibitor with proven antitumor activity and without toxic effects reported.
Valérie Jaulneau et al.
Journal of biomedicine & biotechnology, 2010, 525291-525291 (2010-05-07)
The industrial use of elicitors as alternative tools for disease control needs the identification of abundant sources of them. We report on an elicitor obtained from the green algae Ulva spp. A fraction containing most exclusively the sulfated polysaccharide known
Molly Stapleton et al.
Molecular genetics and metabolism reports, 22, 100563-100563 (2020-01-21)
Mucopolysaccharidoses (MPS) are a family of lysosomal storage disorders which can lead to degenerative and irreversible skeletal, cardiovascular, pulmonary, and neurological damage. Current treatments, including hematopoietic stem cell transplantation and enzyme replacement therapy, have been found most effective if administered
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service