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Safety Information

M140

Sigma-Aldrich

Methylcarbamylcholine chloride

solid, ≥97% (NMR)

Synonym(s):

Methylcarbachol

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About This Item

Linear Formula:
(CH3)3N+CH2CH2OC(O)NHCH3 Cl-
CAS Number:
14721-76-7
Molecular Weight:
196.68
MDL number:
MFCD00153832
UNSPSC Code:
12352200

Assay

≥97% (NMR)

form

solid

storage condition

desiccated

color

white

solubility

H2O: soluble
methanol: soluble

Gene Information

human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143)

Biochem/physiol Actions

Studies of correlation between receptor changes and behavioral function as result of chronic administration of the nicotinic agonist, methylcarbamylcholine (MCC) or the competitive antagonist dihydro-beta-erythroidine (DHBE) in rats shown that the treatment reversibly increased the apparent Bmax and Kd of cortical nAChRs in a dose- and time-dependent manner. DHBE pretreatment inhibited the MCC-induced behavioral changes. The time course of the development of tolerance to MCC as well as the extent of inhibition of DHBE were well correlated with the time course for receptor up-regulation and inhibition of the increase in binding parameters, respectively. Like chronic MCC treatment, chronic DHBE increased the number of [3H]cytisine binding sites but without concomitant development of behavioral tolerance. DHBE pretreatment inhibited the MCC-induced behavioral changes.

Caution

Hygroscopic

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
086K4606
072K4606

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D M Araujo et al.
Journal of neurochemistry, 51(1), 292-299 (1988-07-01)
The present experiments show that N-[3H]-methylcarbamylcholine ([3H]MCC) binds specifically and with high affinity to rat hippocampus, frontal cortex, and striatum. The highest maximal density of binding sites was apparent in frontal cortex and the lowest in hippocampus. [3H]MCC binding was
S J Lansdell et al.
Neuropharmacology, 39(4), 671-679 (2000-03-23)
A series of cell lines stably expressing recombinant nicotinic acetylcholine receptors (nAChRs) has been established by transfection of mammalian (rat) and insect (Drosophila) nicotinic subunit cDNAs. By equilibrium radioligand binding, we have examined the influence of individual subunits upon the
X Yang et al.
The Journal of pharmacology and experimental therapeutics, 271(2), 651-659 (1994-11-01)
Chronic administration of nicotine results in increased numbers of specific nicotinic acetylcholine receptors (nAChRs) within the central nervous system. The purpose of this study was to determine: 1) whether chronic administration of the nicotinic agonist, methylcarbamylcholine (MCC) or the competitive
P A Lapchak et al.
Journal of neurochemistry, 52(2), 483-491 (1989-02-01)
It has been reported that N-methylcarbamylcholine (MCC), a nicotinic agonist, binds to central nicotinic receptors and causes an increase of acetylcholine (ACh) release from certain central cholinergic nerve terminals. The present experiments determine whether these two phenomena change in response

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