M0938
7-Methoxycoumarin-4-Acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(DNP)-D-Arg-amide
>97% (HPLC), solid
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Empirical Formula (Hill Notation):
C85H122N22O19
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Quality Level
Assay
>97% (HPLC)
form
solid
storage temp.
−20°C
Gene Information
human ... CTSD(1509) , CTSE(1510)
mouse ... CTSD(13033) , CTSE(13034)
rat ... CTSD(171293) , CTSE(25424)
Related Categories
Amino Acid Sequence
MCA-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-DNP-Arg-NH2
Application
7-methoxycoumarin-4-acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(DNP)-DArg-amide has been used as a fluorogenic substrate for the quantification of cathepsin D in decapod crustaceans.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Substrates
Substrate for cathepsin D and E.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Cold-adapted digestive aspartic protease of the clawed lobsters Homarus americanus and Homarus gammarus: biochemical characterization
Liliana Rojo
Marine Biotechnology (2013)
Is digestive cathepsin D the rule in decapod crustaceans?
Martinez A D, et al.
Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 215, 31-38 (2018)
Multiple effects of pepstatin A on Trypanosoma cruzi epimastigote forms.
Sangenito LS
Parasitology Research (2012)
Diana Martínez-Alarcón et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 215, 31-38 (2017-10-17)
Cathepsin D is an aspartic endopetidase with typical characteristics of lysosomal enzymes. Cathepsin D activity has been reported in the gastric fluid of clawed lobsters where it acts as an extracellular digestive enzyme. Here we investigate whether cathepsin D is
Bianca Santos Henriques et al.
Frontiers in physiology, 11, 509310-509310 (2021-02-02)
Rhodnius prolixus is one important vector for the parasite Trypanosoma cruzi in Latin America, where Chagas disease is a significant health issue. Although R. prolixus is a model for investigations of vector-parasite interaction and transmission, not much has been done
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