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M0880

Sigma-Aldrich

Ethyl methanesulfonate

liquid

Synonym(s):

Ethyl mesylate, Methanesulfonic acid ethyl ester

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About This Item

Linear Formula:
CH3SO3CH2CH3
CAS Number:
62-50-0
Molecular Weight:
124.16
Beilstein:
773969
EC Number:
200-536-7
MDL number:
MFCD00007559
UNSPSC Code:
12352108
PubChem Substance ID:
24896575
NACRES:
NA.25

form

liquid

Quality Level

200

refractive index

n20/D 1.418 (lit.)

bp

85-86 °C/10 mmHg (lit.)

density

1.206 g/mL at 20 °C

SMILES string

CCOS(C)(=O)=O

InChI

1S/C3H8O3S/c1-3-6-7(2,4)5/h3H2,1-2H3

InChI key

PLUBXMRUUVWRLT-UHFFFAOYSA-N

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Application

Ethyl methanesulfonate had been used for inducing mutation in mouse embryonic fibroblasts, yeast human embryonic kidney cell lines and human lymphocytes.

Biochem/physiol Actions

Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. EMS induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. EMS is potential chemical mutagen used for inducing mutation in rice, wheat and Arabidopsis thaliana.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1

WGK

WGK 3

Flash Point(F)

212.0 °F

Flash Point(C)

100 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. I have heard that I need to use sodium thiosulfate with Product M0880, Ethyl methanesulfonate (EMS), but I’m not sure how. Can you tell me?

    EMS is a mutagen. After treating cells with EMS, the mutagenesis reaction may be stopped by adding the appropriate volume of a 5% sodium thiosulfate solution.The use of a 10% sodium thiosulfate solution with 1% TWEEN 20 has been used to clean surfaces and items such as pipettes that have been contaminated with EMS in mineral oil.

  4. Is Product M0880, Ethyl methanesulfonate (EMS), sterile?

    It is not necessarily sterile. For those applications that require a sterile EMS solution, the EMS should be added to the appropriate buffer or medium. The buffer or medium should then be sterile-filtered.

  5. I received a liquid. What is Product M0880, Ethyl methanesulfonate (EMS), dissolved in?

    It’s actually not dissolved in anything. Pure EMS is itself a liquid at room temperature; that is, the melting point is below room temperature.

  6. How does Product M0880, Ethyl methanesulfonate (EMS), compare to Product 64292, which is the same chemical?

    Product No. 64292 is tested for purity by a titration assay. Although M0880 is likely to be of similar quality, there is no purity assay performed on it.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Genes, 11(11) (2020-10-30)
Lateral root development is a complex process regulated by numerous factors. An important role for sugar in lateral root development has been known for a while, but the underlying molecular basis still remains unclear. In this study, we first showed
Genotoxicity Effect of Ethyl Methanesulfonate on Root Tip Cells of Chilli (Capsicum annuum L.)
Devi AS and Mullainathan L
World Journal of Agricultural Sciences, 7(4), 368-374 (2011)
Kade M Power et al.
PLoS genetics, 16(10), e1009052-e1009052 (2020-10-17)
Ciliary microtubules are subject to post-translational modifications that act as a "Tubulin Code" to regulate motor traffic, binding proteins and stability. In humans, loss of CCP1, a cytosolic carboxypeptidase and tubulin deglutamylating enzyme, causes infantile-onset neurodegeneration. In C. elegans, mutations
Novel wine yeast with ARO4 and TYR1 mutations that overproduce `floral?aroma compounds 2-phenylethanol and 2-phenylethyl acetate
Cordente AG, et al.
Applied Microbiology and Biotechnology, 1-12 (2018)
Yu-Long Gao et al.
Journal of integrative plant biology, 62(2), 165-180 (2019-01-31)
Targeting-induced local lesions in genomes (TILLING) is a powerful reverse-genetics tool that enables high-throughput screening of genomic variations in plants. Although TILLING has been developed for many diploid plants, the technology has been used in very few polyploid species due
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