M0627
7-Methylguanosine
≥90%, synthetic, powder
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About This Item
Empirical Formula (Hill Notation):
C11H15N5O5
CAS Number:
Molecular Weight:
297.27
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Beilstein/REAXYS Number:
3713683
Assay:
≥90%
Biological source:
synthetic
Form:
powder
Solubility:
water: 50 mg/mL, clear to hazy, colorless to faintly yellow
Storage temp.:
2-8°C
Product Name
7-Methylguanosine, ≥90%
InChI
1S/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/t4-,6-,7-,10-/m1/s1
SMILES string
C[n+]1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c3nc(N)nc([O-])c13
InChI key
OGHAROSJZRTIOK-KQYNXXCUSA-N
biological source
synthetic
assay
≥90%
form
powder
solubility
water: 50 mg/mL, clear to hazy, colorless to faintly yellow
storage temp.
2-8°C
Quality Level
General description
7-Methylguanosine structure is also referred to as a cap. It is located on the 5′ end of the cytoplasmic mRNA.
Application
7-Methylguanosine has been used in the removal of residual phosphates from pre rigor solution, phosphate mop system and phosphorous standard solution.
Biochem/physiol Actions
7-Methylguanosine is involved in the processing of a cap-dependent translational process of mRNA. It is also involved in protecting the mRNA from degradation due to ribonucleases and mediate nuclear export. 7-Methylguanosine also permits the recruitment of ribosome.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Saif Eddine Djemal et al.
BMC veterinary research, 14(1), 296-296 (2018-10-01)
A rising isolation trend of drug-resistant M. bovis from human clinical cases is documented in the literature. Here we assessed Mycobacterium tuberculosis complex isolates from cattle for drug susceptibility by the gold standard agar proportion method and a simplified resazurin
Streamlined purification of fluorescently labeled Escherichia coli phosphate-binding protein (PhoS) suitable for rapid-kinetics applications
Smith D D, et al.
Analytical Biochemistry, 537(10), 106-113 (2017)
The eukaryotic translation initiation factor 4E (eIF4E) as a therapeutic target for cancer
Advances in Protein Chemistry and Structural Biology, 101, 1-26 (2015)
Guanghui Hu et al.
Biochemistry, 41(24), 7677-7687 (2002-06-12)
The N7-methylguanine portion of the mRNA cap structure interacts with cap-binding proteins via an unusual double-stacking arrangement in which the positively charged cap is sandwiched between two parallel-oriented aromatic protein side chains. Three-dimensional costructures of cap with two mRNA cap-binding
Interdomain communication of the Chd1 chromatin remodeler across the DNA gyres of the nucleosome
Nodelman I M, et al.
Molecular Cell, 65(3), 447-459 (2017)
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