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Merck
CN

M0388

6α-Methyl-11β-hydroxyprogesterone

Synonym(s):

11β-Hydroxy-6α-methyl-4-pregnene-3,20-dione, Medrysone

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About This Item

Empirical Formula (Hill Notation):
C22H32O3
CAS Number:
2668-66-8
Molecular Weight:
344.49
NACRES:
NA.77
PubChem Substance ID:
24896551
UNSPSC Code:
12352200
EC Number:
220-208-7
MDL number:
MFCD00056477

Key Documents

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InChI key

GZENKSODFLBBHQ-ILSZZQPISA-N

InChI

1S/C22H32O3/c1-12-9-15-17-6-5-16(13(2)23)22(17,4)11-19(25)20(15)21(3)8-7-14(24)10-18(12)21/h10,12,15-17,19-20,25H,5-9,11H2,1-4H3/t12-,15-,16+,17-,19-,20+,21-,22+/m0/s1

SMILES string

[H][C@@]12C[C@H](C)C3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O

sterility

non-sterile

form

solid

shipped in

ambient

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... NR3C1(2908)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
058F0271
058F02711

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Management of vernal conjunctivitis with steroid induced glaucoma--a comparative study.
S Mithal et al.
Indian journal of ophthalmology, 35(5-6), 298-301 (1987-01-01)
N L Verbey et al.
Current eye research, 7(6), 557-561 (1988-06-01)
The effect of topical administration of 3-isobutyl-methyl-xanthine (IBMX), a potent phosphodiesterase inhibitor, was studied on an experimentally provoked uveitis in rabbits. After presensitization with an intravitreal injection of human serum albumin (HSA), intravenous antigenic challenge induces blood-aqueous barrier breakdown and
Lyvia M V Carneiro et al.
Neurotoxicology and teratology, 27(4), 585-592 (2005-07-26)
The work studied behavioral and neurochemical alterations in 21-day-old pups, from both sexes (26 g on average) born from female Wistar rats administered daily with ethanol (0.5 or 4.0 g/kg, p.o.), for 30 days before mating, and throughout their gestational
J F Recasens et al.
Ophthalmic research, 22(1), 12-18 (1990-01-01)
Superoxide dismutase activity (SOD) was measured in the irides of control animals and 24 h after the intravitreal administration of Escherichia coli endotoxin. A 3-fold increase in SOD was noted (p less than 0.001). To protect against the inflammatory process
K Green et al.
Current eye research, 8(3), 317-320 (1989-03-01)
The interaction between a topically administered progesterone, medrysone, and a steroid antagonist, mifepristone, on rabbit intraocular pressure (IOP) has been determined. Medrysone alone increased IOP significantly above parallel controls over the first three weeks; this increase was not sustained. When
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