M0317
Microsomes from Liver, Pooled
from human
Synonym(s):
Liver Microsomes
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About This Item
UNSPSC Code:
12161501
NACRES:
NA.47
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Application
Microsomes from liver have been used to study the in vitro effect of Clinacanthus nutans leaves on the activity of cytochrome P450 3A4 and 2E1.
Biochem/physiol Actions
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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Verawan Uchaipichat
Drug metabolism and pharmacokinetics, 33(1), 67-76 (2017-12-16)
This study aimed to investigate the liver microsomal inhibitory effects of silybin, silychristin, andrographolide, and curcumin by using morphine as an in vitro UGT2B7 probe substrate, and predict the magnitude of the herb-drug interaction arising from these herbal constituents' inhibition in vivo.
Britta Heinze et al.
European journal of nuclear medicine and molecular imaging, 49(1), 301-310 (2021-07-04)
Adrenal tumors represent a diagnostic and therapeutic challenge. Promising results have been obtained through targeting the cytochrome P450 enzymes CYP11B1 and CYP11B2 for molecular imaging, and [123/131I]iodometomidate ([123/131I]IMTO) has even been successfully introduced as a theranostic agent. As this radiopharmaceutical
Anand Joshi et al.
Cancer chemotherapy and pharmacology, 86(4), 535-545 (2020-09-20)
Carboplatin dose is calculated based on kidney function, commonly estimated with imperfect creatinine-based formulae. Iohexol is used to measure glomerular filtration rate (GFR) and allows calculation of a more appropriate carboplatin dose. To address potential concerns that iohexol administered during
Cytotoxicity and cytochrome P450 inhibitory activities of Clinacanthus nutans
Sukh Yen Khua
Drug metabolism and personalized therapy (2017)
Jeffry Adiwidjaja et al.
British journal of clinical pharmacology, 86(10), 2080-2094 (2020-04-07)
This study aimed to investigate the potential interaction between Schisandra sphenanthera, imatinib and bosutinib combining in vitro and in silico methods. In vitro metabolism of imatinib and bosutinib using recombinant enzymes and human liver microsomes were investigated in the presence
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