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Merck
CN

L9668

Lidoflazine

≥98% (HPLC), powder

Synonym(s):

4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide

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About This Item

Empirical Formula (Hill Notation):
C30H35F2N3O
CAS Number:
3416-26-0
Molecular Weight:
491.62
NACRES:
NA.77
PubChem Substance ID:
329817673
UNSPSC Code:
12352200
EC Number:
222-312-8
MDL number:
MFCD00057353

Key Documents

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InChI

1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)

InChI key

ZBIAKUMOEKILTF-UHFFFAOYSA-N

SMILES string

Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

HERG calcium channel blocker
Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. It prolongs QT interval by blocking HERG channel. IC50 < 0.1 μM

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000419384
0000419384
0000073818
127K4606V
0000073818

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W J Flameng et al.
The Annals of thoracic surgery, 61(2), 621-628 (1996-02-01)
Factors determining the outcome of operative correction of valvular abnormalities combined with coronary artery bypass grafting are still incompletely defined. Determinants of early and late (more than 90 days) deaths and event-free survival were studied for combined valve operations and
L Noyez et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 6(7), 377-381 (1992-01-01)
The concept of pretreatment of the myocardium with a pharmacological agent protecting the cell against ischemic and reperfusion injury is very attractive. Lidoflazine, a calcium overload blocker, predominantly membrane stabilizing, is able to prevent cell damage during ischemic arrest and
J Jacobsson et al.
Cryobiology, 29(3), 305-309 (1992-06-01)
The purpose of this study was to investigate the possibility of improving the organ preservation properties of the University of Wisconsin (UW) solution by adding the calcium entry blocker lidoflazine. We also investigated the possibility of decreasing the cold ischemia
John M Ridley et al.
Journal of molecular and cellular cardiology, 36(5), 701-705 (2004-05-12)
Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. We investigated whether or not lidoflazine inhibits current through the rapid delayed rectifier K(+) channel alpha subunit (encoded by HERG -
P Vaagenes et al.
Resuscitation, 35(1), 41-52 (1997-08-01)
We explored the hypothesis that brain damage after cardiac arrest caused by ventricular fibrillation (VF) needs different therapies than that after asphyxiation, which has been studied less thoroughly. In 67 healthy mongrel dogs of both sexes cardiac arrest (at normothermia)
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