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Safety Information

L9655

Sigma-Aldrich

Linoleic Acid-Oleic Acid-Albumin, 100x

liquid, sterile-filtered, BioReagent, suitable for cell culture

Synonym(s):

Fatty Acid-Albumin-complexes

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.75
To inquire about this product L9655, please contact your local Merck office or dealer. Contact Technical Service

biological source

protein from bovine

sterility

sterile-filtered

product line

BioReagent

form

liquid

composition

linoleic acid and oleic acid, 2 mol/mol albumin (each)

concentration

100 mg/mL BSA in DPBS

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

storage temp.

2-8°C

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color

Detection reagent 1: Colorless Detection reagent 2: Colorless

color

Detection reagent 1: Colorless Detection reagent 2: Colorless

color

Detection reagent 1: Colorless Detection reagent 2: Colorless

color

Detection reagent 1: Colorless Detection reagent 2: Colorless

feature

wetted part: no

feature

wetted part: no

feature

wetted part: no

feature

wetted part: no

packaging

pkg of 1 kit

packaging

pkg of 1 kit

packaging

pkg of 1 kit

packaging

pkg of 1 kit

manufacturer/tradename

Cytiva RPN2134

manufacturer/tradename

Cytiva RPN2106

manufacturer/tradename

Cytiva RPN2209

manufacturer/tradename

Cytiva RPN2109

General description

Fatty Acid-Albumin-complexes have been employed as alternative sources of lipids in the development of serum-free media. Fatty acids bind to serum proteins in high proportions. Such proteins may release beneficial fatty acids and bind those that are inhibitory. Oleic acid bound to bovine serum albumin (BSA) is beneficial to the growth of a variety of cell types (e.g., baby hamster kidney (BHK) hybridoma). A mixture of poly-unsaturated and monosaturated fatty acids (i.e., linoleic acid and oleic acid) produces synergistic effect when used as a media supplement.

Application

Linoleic Acid-Oleic Acid-Albumin, 100x has been used:
  • to induce acute hepatocellular stress in primary hepatocytes [1]
  • to induce oxidative stress in cytotrophoblasts[2]
  • to induce lipid droplet accumulation in HepG2 cells[3]

related product

Product No.
Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

含少量动物源组分生物产品

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    0000315835
    0000294577
    0000315835
    0000294577
    SLCP5387

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    Find documentation for the products that you have recently purchased in the Document Library.

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    Laura Moody et al.
    Biochimica et biophysica acta. Gene regulatory mechanisms, 1862(2), 141-152 (2019-01-04)
    Carnitine palmitoyltransferase 1 (Cpt1a) is a rate-limiting enzyme that mediates the transport of fatty acids into the mitochondria for subsequent beta-oxidation. The objective of this study was to uncover how diet mediates the transcriptional regulation of Cpt1a. Pregnant Sprague Dawley
    Pierluigi Ramadori et al.
    Free radical biology & medicine, 91, 114-126 (2015-12-25)
    Generation of reactive oxygen species (ROS) in response to fatty acids accumulation has been classically proposed as a possible "second hit" triggering progression from simple steatosis to non-alcoholic steatohepatitis (NASH). In this study we challenged hepatocyte-specific Keap1 knockout mice (Keap1(Δhepa))
    Anna Virginia Adriana Pirozzi et al.
    Antioxidants (Basel, Switzerland), 10(1) (2021-01-06)
    Several plant extracts are acquiring increasing value because of their antioxidant activity and hypolipidemic properties. Among them, great interest has been recently paid to açai fruit as a functional food. The aim of this study was to test the ability
    Liang Tian et al.
    International journal of molecular sciences, 20(5) (2019-03-13)
    This study aimed to characterize the full-length cDNA of MARK4 in Sus scrofa, and evaluated its potential role in the regulation of lipid accumulation in pig placental trophoblasts and analyzed signaling pathways involved, thereby providing insights into mechanisms for placental
    Jan Frohlich et al.
    Biochimica et biophysica acta. Molecular and cell biology of lipids, 1866(6), 158920-158920 (2021-03-09)
    Hepatocellular carcinoma (HCC) is one of the fastest-growing causes of cancer-related mortalities worldwide and this trend is mimicked by the surge of non-alcoholic fatty liver disease (NAFLD). Altered hepatic lipid metabolism promotes HCC development through inflammation and activation of oncogenes.
    View All Related Papers

    Articles

    Linoleic acid in Cell Culture

    Importance and uses of linoleic acid in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

    Oleic Acid in Cell Culture

    How the unsaturated fatty acid, oleic acid and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.

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