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Merck
CN

L9169

L-838,417

≥98% (HPLC)

Synonym(s):

3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine

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About This Item

Empirical Formula (Hill Notation):
C19H19F2N7O
CAS Number:
286456-42-6
Molecular Weight:
399.40
NACRES:
NA.77
PubChem Substance ID:
329817670
UNSPSC Code:
12352200
MDL number:
MFCD08690609

Key Documents

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Product Name

L-838,417, ≥98% (HPLC)

InChI

1S/C19H19F2N7O/c1-19(2,3)13-8-15-24-25-17(12-7-11(20)5-6-14(12)21)28(15)26-18(13)29-9-16-22-10-23-27(16)4/h5-8,10H,9H2,1-4H3

SMILES string

Cn1ncnc1COc2nn3c(nnc3cc2C(C)(C)C)-c4cc(F)ccc4F

InChI key

BQDUNOMMYOKHEP-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥20 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

−20°C

Biochem/physiol Actions

L-838,417 is a novel pharmacology with no efficacy at a 1 subtype, but is partial agonist with equal efficacy at α2, K3 and α5 subtypes.
L-838,417 is a partial agonist with equal efficacy at α2, K3, and α5 subtypes.

Features and Benefits

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
029K4611V
029K46111
029K4611

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