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L8912

Sigma-Aldrich

L-Leucine

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, JP, USP testing specifications

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Synonym(s):
(S)-Leucine, (S)-2-Amino-4-methylpentanoic acid
Linear Formula:
(CH3)2CHCH2CH(NH2)CO2H
CAS Number:
61-90-5
Molecular Weight:
131.17
Beilstein:
1721722
EC Number:
200-522-0
MDL number:
MFCD00002617
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24896510
NACRES:
NA.26

biological source

non-animal source

Quality Level

300

Agency

USP/NF
meets EP testing specifications
meets JP testing specifications
meets USP testing specifications

Assay

98.5-101.0%

form

powder

optical activity

[α]20/D 14.9 to 16.0°, c = 4 in 6 M HCl
[α]25/D 14.9 to 17.3 °, c = 4 in 6 M HCl

quality

meets EP, JP, USP testing specifications

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

>300 °C (lit.)

solubility

1 M HCl: 50 mg/mL

cation traces

As: ≤1 ppm
Fe: ≤10 ppm
NH4+: <0.02%
heavy metals: ≤10 ppm

application(s)

peptide synthesis
pharmaceutical (small molecule)

functional group

amine
carboxylic acid

storage temp.

room temp

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

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General description

Leucine is a non-glucogenic, and essential amino acid. It is a branched-chain amino acid that is a structural component of proteins.

Application

L-Leucine has been used:

  • as a hypertrophic agent to monitor its effects on myotubes.
  • as a component of PMG media for culturing yeast.
  • in myotube protein synthesis analysis in skeletal muscle cells.
  • to study its effects on hepatic lipid metabolism.

Biochem/physiol Actions

Leucine plays a role in intracellular signaling, gene transcription, and translation. It promotes the synthesis of protein by activating the mammalian target of the rapamycin (mTOR) signaling pathway in placental cells, skeletal muscles, and adipose tissue. Leucine inhibits protein degradation and promotes mitochondrial biogenesis, glucose metabolism, and fatty acid oxidation to provide energy for protein synthesis.

Other Notes

For additional information on our range of Biochemicals, please complete this form.
The product is intended for laboratory use only, and it is not suitable for drug, household, or other purposes.

Application

Product No.
Description
Pricing

comparable product

Product No.
Description
Pricing

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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(-)-Epicatechin and its colonic metabolite hippuric acid protect against dexamethasone-induced atrophy in skeletal muscle cells
Edwards S J, et al.
The Journal of Nutritional Biochemistry, 110, 109150- 109150 (2022)
Optimization of an in vitro bioassay to monitor growth and formation of myotubes in real time
Sylvia M
Bioscience Reports (2016)
Leucine in Obesity: Therapeutic Prospects
Yao K, et al.
Trends in Pharmacological Sciences, 37(8), 714-727 (2016)
The role of leucine and its metabolites in protein and energy metabolism
Duan Y, et al.
Amino Acids, 48(1), 41-51 (2016)
Eric R. Braverman
The Healing Nutrients Within: Facts, Findings, and New Research on Amino Acids (2003)
View All Related Papers

Chromatograms

application for HPLC

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