L8638
Long chain alkylamine controlled pore glass
120-200 mesh, nominal diameter 500 Å
Synonym(s):
LCAA-CPG
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About This Item
MDL number:
UNSPSC Code:
12352200
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particle size
120-200 mesh
pore size
500 Å nominal diameter
Application
Long chain alkylamine controlled pore glass is used in chromatography. Long chain alkylamine controlled pore glass has been used to develop a novel method for the immobilization of nucleotides and for the synthesis of DNA oligonucleotides and their 3′- or (3′,5′)-conjugates.
Other Notes
Ligand is mixture of primary and secondary alkylamines, approx. 1:1.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Release of DNA oligonucleotides and their conjugates from controlled-pore glass under thermolytic conditions
Grajkowski, A., et al.
Current Protocols in Nucleic Acid Chemistry / Edited By Serge L. Beaucage ... [Et Al.], 3-3 (2008)
Caren L Freel Meyers et al.
Organic letters, 5(3), 341-344 (2003-01-31)
[reaction: see text] A novel method for the immobilization of nucleotides has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes nucleophilic attack by long-chain alkylamine-controlled pore glass (LCAA-CPG) to generate an immobilized nucleotide. Quantification
Andrzej Grajkowski et al.
Bioconjugate chemistry, 19(8), 1696-1706 (2008-07-24)
The functionalization of long chain alkylamine controlled-pore glass (CPG) with a 3-hydroxypropyl-(2-cyanoethyl)thiophosphoryl linker and its conversion to the support 7 has led to the synthesis of DNA oligonucleotides and their 3'- or (3',5')-conjugates. Indeed, CPG support 7 has been successfully
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