L8275
Lectin from Galanthus nivalis (snowdrop)
lyophilized powder
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Synonym(s):
Galanthus nivalis lectin, GNL
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form
lyophilized powder
Quality Level
potency
<20 μg per mL agglutination activity
composition
Protein, ≥90% Lowry
impurities
salt, essentially free
storage temp.
2-8°C
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General description
Lectin from Galanthus nivalis (snowdrop) is a tetrameric, 12 kDa mannose binding lectin. It belongs to the family, Amaryllidacea. It is specific to α-1,3- or 1,6- linked D-mannose of carbohydrates. Snowdrop lectins are toxic to insects.
Application
Lectin from Galanthus nivalis (snowdrop) has been used:
- to coat ELISA plates
- as reverse transcriptase inhibitor
- in ELISA for detection of envelope glycoproteins of the human and simian immunodeficiency viruses
Biochem/physiol Actions
Lectin from Galanthus nivalis (snowdrop) provide resistance against pests and are used in transgenic plants. Snowdrop lectin functions as a carrier to transport fused proteins to the hemolymph as it crosses gut epithelium of target species to exhibit insecticidal effects.
GNL agglutinates rabbit erythrocytes; human erythrocytes are not agglutinated. GNL sugar specificity is directed to the nonreducing end of the terminal α-D-mannosyl residue of glycoconjugates.
Preparation Note
Purified by affinity chromatography according to Kaku.
Analysis Note
Agglutination activity is expressed in μg/ml and is determined from serial dilution in phosphate buffered saline, pH 7.2 of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of rabbit erythrocytes after 1 hr incubation at 25 °C.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
监管及禁止进口产品
Certificates of Analysis (COA)
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Snowdrop lectin.
H Kaku et al.
Methods in enzymology, 179, 327-331 (1989-01-01)
A model for the hepatitis C virus envelope glycoprotein E2
Yagnik AT, et al.
Proteins: Structure, Function, and Bioinformatics, 40, 355-366 (2000)
Jacklyn Johnson et al.
Journal of virology, 94(9) (2020-02-28)
Semen is the primary transmission vehicle for various pathogenic viruses. Initial steps of transmission, including cell attachment and entry, likely occur in the presence of semen. However, the unstable nature of human seminal plasma and its toxic effects on cells
Direct effects of snowdrop lectin (GNA) on larvae of three aphid predators and fate of GNA after ingestion
Hogervorst PAM, et al.
Journal of Insect Physiology, 52, 614-624 (2006)
Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus
Antiviral Research, 88, 25-30 (2010)
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