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L8170

Sigma-Aldrich

Pseudolaric Acid B

≥98% (HPLC)

Synonym(s):

(-)-Pseudolaric acid B, O-Acetylpseudolaric acid C, Pseudolarix acid B

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About This Item

Empirical Formula (Hill Notation):
C23H28O8
CAS Number:
82508-31-4
Molecular Weight:
432.46
MDL number:
MFCD26960905
UNSPSC Code:
12352106
NACRES:
NA.25

biological source

Larix kaempferi

Assay

≥98% (HPLC)

form

powder or crystals

storage condition

protect from light

color

white to off-white

solubility

methanol: 1 mg/mL, clear, colorless

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

O=C(OC)C1=CC[C@@]2(C(O[C@@](/C=C/C=C(C(O)=O)\C)(C)[C@@H]3CC2)=O)[C@]3(OC(C)=O)CC1

InChI

1S/C23H28O8/c1-14(17(24)25)6-5-10-21(2)16-9-12-22(19(27)31-21)11-7-15(18(26)29-3)8-13-23(16,22)20(28)30-4/h5-7,10,16H,8-9,11-13H2,1-4H3,(H,24,25)/b10-5+,14-6+/t16-,21+,22+,23+/m0/s1

InChI key

XRLYZNSOXNPKOR-CBDALDGHSA-N

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Biochem/physiol Actions

Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi. It has shown antifungal, antifertility, and antiangiogenic properties. It also may exihibit anti-cancer and anti-inflammatory properties.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H361fd

Precautionary Statements

P201 - P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLBB1866V

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Jingtao Liu et al.
Acta biochimica et biophysica Sinica, 44(6), 490-502 (2012-05-04)
Angiogenesis inhibitors combined with chemotherapeutic drugs have significant efficacy in the treatment of a variety of cancers. Pseudolarix acid B (PAB) is a traditional pregnancy-terminating agent, which has previously been shown to reduce tumor growth and angiogenesis. In this study
Gengqing Qu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(24), 3535-3538 (2012-03-01)
To investigate the apoptosis of bladder cancer cell 5637 induced by pseudolaric acid B in vitro and its mechanism. The cell proliferation was detected by MTT assay;the cell cycle was measured by flow cytometry; the cell apoptosis was observed by
Na Guo et al.
Mycoses, 54(5), e400-e406 (2011-09-14)
Candida albicans is the most common fungal pathogen in humans. The emergence of resistance to azole antifungals has raised the issue of using such antifungals in combination to optimise therapeutic outcome. The objective of this study was to evaluate in
Barry M Trost et al.
Journal of the American Chemical Society, 130(48), 16424-16434 (2008-11-13)
We report a full account of our work toward the total synthesis of pseudolaric acid B (1a), a diterpene acid isolated from the bark of Pseudolarix kaempferi Gordon (pinaceae). Compound 1a is an antifungal and antifertility agent. Furthermore, its capacity
Xiaoyuan Lei et al.
Journal of chromatography. A, 1216(11), 2179-2184 (2008-06-25)
An efficient and convenient method, biological fingerprinting chromatogram analysis is presented, which is applied to the comparison of fingerprinting chromatograms of the extracts of Chinese herbal medicines after the interaction with biological systems (cell, DNA, protein, etc.). The method was
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