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L8045

Liquiritin

Name: Liquiritin
Brand: SIGMA

from Glycyrrhizae root (licorice root), ≥98% (HPLC)

Synonym(s):

4′,7-Dihydroxyflavanone 4′-glucoside, Liquiritoside

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₂O₉

CAS Number:

551-15-5

Molecular Weight:

418.39

MDL number:

MFCD00210526

UNSPSC Code:

12352200

NACRES:

NA.25

biological source

Glycyrrhizae root (licorice root)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

O=C1C2=CC=C(O)C=C2O[C@H](C3=CC=C(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)C=C3)C1

InChI

1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1

InChI key

DEMKZLAVQYISIA-ZRWXNEIDSA-N

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General description

Liquiritin is a type of flavone, present as an active ingredient in Glycyrrhiza uralensis and Glycyrrhiza glabra extract. It is a constituent of many traditional Chinese medicine formulas popularly used as a cure for asthma, peptic ulcers, and cough.

Application

Liquiritin has been used to analyze the extract of Glycyrrhiza uralensis and examine its components for anti-Hepatitis C virus activity.

Biochem/physiol Actions

Liquiritin has been attributed to show antidepressant-like and antioxidant activity. It causes apoptosis in cell lines having gastric cancer and promyelocytic leukemia. Liquiritin also demonstrates neurotrophic effects and hence has been considered as a potential contender for the management of different neurodegenerative diseases. It shows an anti-inflammatory property with protection to the liver against oxidative damage. It has depigmenting ability and is a potential medicine for melasma.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Anti-Inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver.

Ji-Yeon Yu et al.

Molecules (Basel, Switzerland), 20(7), 13041-13054 (2015-07-25)

This study provides the scientific basis for the anti-inflammatory effects of licorice extract in a t-BHP (tert-butyl hydrogen peroxide)-induced liver damage model and the effects of its ingredients, glycyrrhizic acid (GA), liquiritin (LQ) and liquiritigenin (LG), in a lipopolysaccharide (LPS)-stimulated

Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats.

Zhiyu Zhao et al.

Behavioural brain research, 194(1), 108-113 (2008-07-29)

Many flavonoids extracted from nature plants have been reported to exert antidepressant-like effect in animal studies. The present study was designed to observe the effects of liquiritin, a flavone compound derived from Glycyrrhiza uralensis, on the behaviors of chronic variable

Liquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cells.

Zheng-Ai Chen et al.

Cytotechnology, 60(1-3), 125-132 (2009-10-01)

Neurite outgrowth and neuronal differentiation play a crucial role in the development of the nervous system. Understanding of neurotrophins induced neurite outgrowth was important to develop therapeutic strategy for axon regeneration in neurodegenerative diseases as well as after various nerve

Antineuropathic pain actions of Wu-tou decoction resulted from the increase of neurotrophic factor and decrease of CCR5 expression in primary rat glial cells.

Qiuyan Guo et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 123, 109812-109812 (2020-01-17)

Wu-tou decoction (WTD), a classic Traditional Chinese medicine formula, has been extensively used in the treatment of neuropathic pain (NP) such as chronic inflammatory pain, trigeminal neuralgia, and cancer-induced pain. Our previous studies have shown that the severity of mechanical

Topical liquiritin improves melasma.

M Amer et al.

International journal of dermatology, 39(4), 299-301 (2000-05-16)

Twenty women with a clinical diagnosis of melasma were treated with liquiritin cream on one side of the face and with a vehicle cream on the other side twice daily for 4 weeks. Patients were advised to avoid sun exposure

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