L8025
Lectin from Maackia amurensis
lyophilized powder
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Synonym(s):
Maackia amurensis agglutinin, MAA
MDL number:
UNSPSC Code:
12352200
Recommended Products
form
lyophilized powder
potency
<10 μg per mL agglutination activity
composition
Protein, ≥85% Lowry
impurities
salt, essentially free
storage temp.
2-8°C
Biochem/physiol Actions
MAA consists of two molecular species, a strongly hemagglutinating hemagglutinin (MAH) and a strongly mitogenic hemagglutinin (MAL). The mitogenic activity of the latter is inhibited by α-sialyl-[2→3]-lactose. MAA interacts with sialic acid-containing glycoconjugate and may be useful for fractionation of sialylated oligosaccharides.
Preparation Note
Purified by affinity chromatography using a modification of the method of Wang and Cummings.
Analysis Note
Agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 7.2 of a 1 mg/ml solution. This activity is the lowest concentration to agglutinate a 2% suspension of human blood group O erythrocytes after 1 hr incubation at 25 °C.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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W C Wang et al.
The Journal of biological chemistry, 263(10), 4576-4585 (1988-04-05)
We recently reported that the purified leukoagglutinin (designated MAL) from the seeds of the leguminous plant Maackia amurensis is a potent leukoagglutinin for the mouse lymphoma cell line BW5147 (Wang, W.-C., and Cummings, R. D. (1987) Anal. Biochem. 161,80). We
Jhon Alberto Ochoa-Alvarez et al.
PloS one, 7(7), e41845-e41845 (2012-07-31)
Cancer is a leading cause of death of men and women worldwide. Tumor cell motility contributes to metastatic invasion that causes the vast majority of cancer deaths. Extracellular receptors modified by α2,3-sialic acids that promote this motility can serve as
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